OBJECTIVE To assess interobserver reproducibility of different regions of interest (ROIs) on multi-parametric renal MRI using commercially available software. MATERIALS AND METHODS Healthy volunteers (HV), patients with heart failure (HF) and renal transplant recipients (Tx) were recruited. Localiser scans, T1 mapping and pseudo-continuous arterial spin labelling (pCASL) were performed. HV and Tx also underwent diffusion-weighted imaging to allow calculation of apparent diffusion coefficient (ADC). For T1, pCASL and ADC, ROIs were drawn for whole kidney (WK), cortex (Cx), user-defined representative cortex (rep-Cx) and medulla. Intraclass correlation coefficient (ICC) and coefficient of variation (CoV) were assessed. RESULTS Forty participants were included (10 HV, 10 HF and 20 Tx). The ICC for renal volume was 0.97 and CoV 6.5%. For T1 and ADC, WK, Cx, and rep-Cx were highly reproducible with ICC ≥ 0.76 and CoV < 5%. However, cortical pCASL results were more variable (ICC > 0.86, but CoV up to 14.2%). While reproducible, WK values were derived from a wide spread of data (ROI standard deviation 17% to 55% of the mean value for ADC and pCASL, respectively). Renal volume differed between groups (p < 0.001), while mean cortical T1 values were greater in Tx compared to HV (p = 0.009) and HF (p = 0.02). Medullary T1 values were also higher in Tx than HV (p = 0.03), while medullary pCASL values were significantly lower in Tx compared to HV and HF (p = 0.03 for both). DISCUSSION Kidney volume calculated by manually contouring a localiser scan was highly reproducible between observers and detected significant differences across patient groups. For T1, pCASL and ADC, Cx and rep-Cx ROIs are generally reproducible with advantages over WK values.

中文翻译：

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比较健康志愿者，心力衰竭患者和肾脏移植受者在多参数肾脏磁共振成像上不同目标区域的观察者之间的可重复性。

目的使用商用软件在多参数肾脏MRI上评估不同目标区域（ROI）的观察者之间的可重复性。材料与方法招募健康志愿者（HV），心力衰竭患者（HF）和肾移植受者（Tx）。进行了定位器扫描，T1映射和伪连续动脉自旋标记（pCASL）。HV和Tx也进行了扩散加权成像，以允许计算表观扩散系数（ADC）。对于T1，pCASL和ADC，绘制了全肾（WK），皮质（Cx），用户定义的代表性皮质（rep-Cx）和髓质的ROI。评估了类内相关系数（ICC）和变异系数（CoV）。结果包括40名参与者（10 HV，10 HF和20 Tx）。肾体积的ICC为0.97，CoV为6.5％。对于T1和ADC，WK，Cx和rep-Cx在ICC≥0.76和CoV <5％时具有很高的重现性。但是，皮质pCASL结果的变化更大（ICC> 0.86，但CoV高达14.2％）。尽管可重现，但WK值是从广泛的数据中得出的（ROI标准偏差分别为ADC和pCASL的平均值的17％至55％）。两组之间的肾体积不同（p <0.001），而与HV（p = 0.009）和HF（p = 0.02）相比，Tx的平均皮质T1值更大。与HV和HF相比，Tx的髓样T1值也比HV高（p = 0.03），而Tx的髓样pCASL值明显更低。讨论通过手动绘制局部扫描轮廓轮廓计算出的肾脏体积在观察者之间具有很高的可重复性，并且在患者组之间发现了显着差异。对于T1，pCASL和ADC，