Comparison between synthetic and conventional magnetic resonance imaging in patients with multiple sclerosis and controls.,Magnetic Resonance Materials in Physics Biology and Medicine

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Comparison between synthetic and conventional magnetic resonance imaging in patients with multiple sclerosis and controls.
Magnetic Resonance Materials in Physics Biology and Medicine ( IF 2.3 ) Pub Date : 2019-11-28 , DOI: 10.1007/s10334-019-00804-9
Francesca Di Giuliano _{1,

2} , Silvia Minosse ₁ , Eliseo Picchi _{1,

2} , Girolama Alessandra Marfia _{3,

4} , Valerio Da Ros ₅ , Massimo Muto ₆ , Mario Muto ₇ , Chiara Adriana Pistolese _{1,

2} , Andrea Laghi ₈ , Francesco Garaci _{1,

2} , Roberto Floris _{1,

2}

Affiliation

Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Viale Oxford 81, 00133, Rome, Italy.
U.O.C Diagnostic Imaging and Neuroradiology, Department of Integrated Care Processes, Fondazione PTV Policlinico "Tor Vergata", University of Rome "Tor Vergata", Viale Oxford 81, 00133, Rome, Italy.
Multiple Sclerosis Clinical and Research Unit, Department of Systems Medicine, University of Rome "Tor Vergata", Viale Oxford 81, 00133, Rome, Italy.
Neurology Unit, Department of Neurosciences, Fondazione PTV Policlinico "Tor Vergata", University of Rome "Tor Vergata", Viale Oxford 81, 00133, Rome, Italy.
Department of Diagnostic Imaging and Interventional Radiology, Policlinico Tor Vergata, Viale Oxford 81, 00133, Rome, Italy.
Department of Neurosciences and Reproductive and Odontostomatological Sciences, University of Naples Federico II, 80100, Naples, Italy.
Department of Neuroradiology, A.O.R.N. Cardarelli, 80100, Naples, Italy.
Department of Surgical and Medical Sciences and Translational Medicine, Radiology Unit, "Sapienza" University of Rome, Sant'Andrea University Hospital, Via di Grottarossa, 1035-1039, 00189, Rome, Italy.

Objectives

Synthetic magnetic resonance imaging (SyMRI) allows to obtain different weighted-images using the multiple-dynamic multiple-echo sequence lasting 6 min. The aim is to compare quantitatively and qualitatively synthetic- and conventional MRI in patients with multiple sclerosis (MS) and controls assessing the contrast (C), the signal to noise ratio (SNR), and the contrast to noise ratio (CNR). We evaluated the lesion count and lesion-to-white matter contrast (\({\text{C}}_{{\text{l } - \text{ WM}}} {)}\) in the MS patients.

Methods and methods

51 patients underwent synthetic- and conventional MRI. Qualitative analysis was evaluated by assigning scores to all synthetic- and conventional MRI sequences by two neuroradiologists. Lesions were counted in MS patients both in the conventional- and synthetic T2-FLAIR. Regions of interest were placed in the cerebrospinal fluid, in the white- and grey matter. For the sequences were evaluated: C, CNR, and SNR.

Results

Synthetic T2-FLAIR images are qualitatively inferior. C and CNR were significantly higher in synthetic T1W and T2W images compared to conventional images, but not for T2-FLAIR. The SNR value was always lower in synthetic images than in conventional ones.

Conclusions

SyMRI can be used in clinical practice because it has a similar diagnostic accuracy which reduces the scanning time compared to the conventional one. However, synthetic T2-FLAIR images need to be improved.

中文翻译：

多发性硬化症和对照患者的合成磁共振成像和常规磁共振成像的比较。

目标

合成磁共振成像（SyMRI）允许使用持续6分钟的多动态多回波序列获得不同的加权图像。目的是定量和定性比较多发性硬化症（MS）和对照患者的MRI和MRI评估对比度（C），信噪比（SNR）和对比度与噪声比（CNR）。我们评估了MS患者的病变计数和病变与白质的对比（\（{\ text {C}} _ {{\ text {l}-\ text {WM}}} {}} \}）。