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Diffusion tensor imaging of the human thigh: consideration of DTI-based fiber tracking stop criteria.
Magnetic Resonance Materials in Physics Biology and Medicine ( IF 2.0 ) Pub Date : 2019-11-27 , DOI: 10.1007/s10334-019-00791-x
Johannes Forsting 1 , Robert Rehmann 1 , Martijn Froeling 2 , Matthias Vorgerd 1 , Martin Tegenthoff 1 , Lara Schlaffke 1
Affiliation  

OBJECTIVES To consider the tract-based analysis of DTI parameters in human muscle by assessing different fiber tracking stop criteria settings on diffusion parameters. MATERIALS AND METHODS 30 healthy volunteers underwent a 3 T MRI. Diffusion-weighted images were acquired to perform DTI and fiber tracking analysis for six thigh muscles. Whole thigh muscles were evaluated by fiber tractography using different fiber tracking stop parameters [FA (0.01-0.15) to (0.4-0.99); angle 10°-30°, step size 0.75 mm, 1.5 mm, 3 mm]. Diffusion and tractography-derived parameters per stop criterion were compared using a repeated measure ANOVA including Bonferroni-corrected post hoc tests. RESULTS We found significant differences in all examined diffusion parameters between different stop criteria (main effect p < 0.001). We showed different influence of tracking parameters on diffusion parameters in examined muscles (main effect p ≤ 0.001). CONCLUSIONS Statistically significant differences in fiber tracking results using different stop criteria were shown. Fiber tracking stop criteria do have an important influence on study results and should be considered in the development of study protocols and comparison of studies. We recommend a FA minimum of 0.10 and a step size lower than voxel size, e.g., a half with a constant ratio between step size and angle of 10°/mm.

中文翻译:

大腿弥散张量成像:基于DTI的纤维跟踪停止标准的考虑。

目的通过评估扩散参数上不同的纤维跟踪停止标准设置来考虑对人体肌肉中DTI参数进行基于道的分析。材料与方法30名健康志愿者接受了3 T MRI检查。采集扩散加权图像以对六个大腿肌肉进行DTI和纤维追踪分析。使用不同的纤维追踪停止参数[FA(0.01-0.15)至(0.4-0.99);通过纤维束摄影术评估大腿肌肉。角度10°-30°,步长0.75 mm,1.5 mm,3 mm]。使用重复测量方差分析(ANOVA)(包括Bonferroni校正的事后检验),比较每个停止标准的扩散和超声影像学得出的参数。结果我们发现,在不同的停止标准之间,所有检查的扩散参数均存在显着差异(主效应p <0.001)。我们显示了跟踪参数对所检查的肌肉中扩散参数的不同影响(主效应p≤0.001)。结论显示了使用不同的停止标准在纤维跟踪结果上的统计学显着差异。光纤跟踪停止标准确实会对研究结果产生重要影响,因此在制定研究方案和进行研究比较时应考虑到这一点。我们建议FA最小值为0.10,步长小于体素大小,例如,步长和角度之间的比率恒定为10°/ mm的一半。光纤跟踪停止标准确实会对研究结果产生重要影响,因此在制定研究方案和进行研究比较时应考虑到这一点。我们建议FA最小值为0.10,步长小于体素大小,例如,步长和角度之间的比率恒定为10°/ mm的一半。光纤跟踪停止标准确实会对研究结果产生重要影响,因此在制定研究方案和进行研究比较时应考虑到这一点。我们建议FA最小值为0.10,步长小于体素大小,例如,步长和角度之间的比率恒定为10°/ mm的一半。
更新日期:2019-11-27
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