Consensus-based technical recommendations for clinical translation of renal BOLD MRI.,Magnetic Resonance Materials in Physics Biology and Medicine

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Consensus-based technical recommendations for clinical translation of renal BOLD MRI.
Magnetic Resonance Materials in Physics Biology and Medicine ( IF 2.0 ) Pub Date : 2019-11-25 , DOI: 10.1007/s10334-019-00802-x
Octavia Bane ₁ , Iosif A Mendichovszky ₂ , Bastien Milani ₃ , Ilona A Dekkers ₄ , Jean-Francois Deux ₅ , Per Eckerbom ₆ , Nicolas Grenier ₇ , Michael E Hall ₈ , Tsutomu Inoue ₉ , Christoffer Laustsen ₁₀ , Lilach O Lerman ₁₁ , Chunlei Liu ₁₂ , Glen Morrell ₁₃ , Michael Pedersen ₁₄ , Menno Pruijm ₁₅ , Elizabeth A Sadowski ₁₆ , Erdmann Seeliger ₁₇ , Kanishka Sharma ₁₈ , Harriet Thoeny ₁₉ , Peter Vermathen ₂₀ , Zhen J Wang ₂₁ , Zbigniew Serafin ₂₂ , Jeff L Zhang ₂₃ , Susan T Francis ₂₄ , Steven Sourbron ₁₈ , Andreas Pohlmann ₂₅ , Sean B Fain ₂₆ , Pottumarthi V Prasad ₂₇

Affiliation

BioMedical Engineering and Imaging Institute and Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, UK.
Center for BioMedical Imaging, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Department of Radiology, Groupe Hospitalier Henri Mondor, Créteil, France.
Department of Radiology, Institution for Surgical Sciences, Uppsala University, Uppsala, Sweden.
Department of Radiology, Université de Bordeaux, CHU de Bordeaux, Bordeaux, France.
Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Department of Nephrology, Faculty of Medicine, Saitama Medical University, Saitama, Japan.
The MR Research Center Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Electrical Engineering and Computer Science, and Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA.
Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, USA.
Department of Clinical Medicine-Comparative Medicine Lab, Aarhus University Hospital, Aarhus, Denmark.
Nephrology and Hypertension Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Institute of Physiology, Charité-University Medicine Berlin, Berlin, Germany.
Imaging Biomarkers Group, Department of Biomedical Imaging Sciences, University of Leeds, Leeds, UK.
Department of Radiology, Hôpital Cantonal Fribourgois, University of Fribourg, Fribourg, Switzerland.
Departments for BioMedical Research and Radiology, Inselspital, Universitaetspital Bern, Bern, Switzerland.
Department of Radiology and Biomedical Imaging, University of California San Francisco Medical Center, San Francisco, CA, USA.
Department of Radiology, Nicolaus Copernicus University, Collegium Medicum, Bydgoszcz, Poland.
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Sir Peter Mansfield Centre, University of Notthingham, Notthingham, UK.
Berlin Ultrahigh Field Facility, Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Departments of Biomedical Engineering, Radiology, and Medical Physics, University of Wisconsin, Madison, WI, USA.
Department of Radiology, Center for Advanced Imaging, NorthShore University Health System, Evanston, IL, USA.

Harmonization of acquisition and analysis protocols is an important step in the validation of BOLD MRI as a renal biomarker. This harmonization initiative provides technical recommendations based on a consensus report with the aim to move towards standardized protocols that facilitate clinical translation and comparison of data across sites. We used a recently published systematic review paper, which included a detailed summary of renal BOLD MRI technical parameters and areas of investigation in its supplementary material, as the starting point in developing the survey questionnaires for seeking consensus. Survey data were collected via the Delphi consensus process from 24 researchers on renal BOLD MRI exam preparation, data acquisition, data analysis, and interpretation. Consensus was defined as ≥ 75% unanimity in response. Among 31 survey questions, 14 achieved consensus resolution, 12 showed clear respondent preference (65-74% agreement), and 5 showed equal (50/50%) split in opinion among respondents. Recommendations for subject preparation, data acquisition, processing and reporting are given based on the survey results and review of the literature. These technical recommendations are aimed towards increased inter-site harmonization, a first step towards standardization of renal BOLD MRI protocols across sites. We expect this to be an iterative process updated dynamically based on progress in the field.

中文翻译：

基于共识的肾脏 BOLD MRI 临床转化技术建议。

采集和分析方案的协调是验证 BOLD MRI 作为肾脏生物标志物的重要一步。该协调计划根据共识报告提供了技术建议，旨在走向标准化协议，促进临床转化和跨站点数据比较。我们使用最近发表的系统综述论文，其中在其补充材料中详细总结了肾脏 BOLD MRI 技术参数和研究领域，作为制定调查问卷以寻求共识的起点。调查数据是通过 Delphi 共识流程从 24 名研究人员收集的，涉及肾脏 BOLD MRI 检查准备、数据采集、数据分析和解释。共识被定义为≥ 75% 的一致响应。在 31 个调查问题中，14 个达成了共识解决，12 个显示了明确的受访者偏好（65-74% 同意），5 个显示受访者之间意见分歧相等（50/50%）。根据调查结果和文献综述，给出了主题准备、数据采集、处理和报告的建议。这些技术建议旨在加强站点间协调，这是跨站点肾脏 BOLD MRI 方案标准化的第一步。我们希望这是一个根据该领域的进展动态更新的迭代过程。

更新日期：2019-11-25

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