Poly(N-vinyl pyrrolidone) (PVP)-based hydrogels with titania nanoparticles (TN) were synthesized by the sol–gel method for the first time and were characterized in different states (native, freeze-dried, air-dried to constant weight and ground to powder, or swollen to constant weight in H2O or D2O) by various methods such as wide-angle and small-angle X-ray and neutron scattering, neutron spin-echo (NSE) spectroscopy, and scanning electron microscopy. The static (static polymer–polymer correlation length (mesh size), associates of cross-links and PVP microchains) and dynamic (polymer chain relaxation rate, hydrodynamic polymer–polymer correlation length) structural elements were determined. The incorporation of titania nanoparticles into PVP hydrogel slightly increases the size of structural inhomogeneities (an increase in the static and dynamic polymer–polymer correlation length, the formation of associates of cross-links and PVP chains). Titania nanoparticles have an impact on the microstructure of the composite hydrogel and form associates with sizes from 0.5 to 2 µm attached to PVP hydrogel pore walls. The PVP and TN/PVP hydrogels show a high degree of water swelling. Moreover, the presence of titania nanoparticles in TN/PVP increases the number of water adsorption cycles compared to PVP hydrogel. The high swelling degree, bacteria-resistant and antimicrobial properties against Staphylococcus aureus allow considering NT/PVP hydrogels for medical applications as wound coatings.

中文翻译：

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二氧化钛纳米粒子聚(N-乙烯基吡咯烷酮)基水凝胶的合成及理化性质


首次采用溶胶-凝胶法合成了含有二氧化钛纳米颗粒（TN）的聚（N-乙烯基吡咯烷酮）（PVP）水凝胶，并在不同状态下（自然状态、冷冻干燥状态、风干至恒重状态）进行了表征。通过各种方法，如广角和小角 X 射线和中子散射、中子自旋回波 (NSE) 光谱和扫描电子显微镜，研磨成粉末，或在 H2O 或 D2O 中溶胀至恒重。确定了静态（静态聚合物-聚合物相关长度（网格尺寸）、交联和 PVP 微链的关联）和动态（聚合物链松弛率、流体动力学聚合物-聚合物相关长度）结构元素。将二氧化钛纳米粒子掺入 PVP 水凝胶中会稍微增加结构不均匀性的大小（静态和动态聚合物-聚合物相关长度的增加，交联和 PVP 链缔合体的形成）。二氧化钛纳米颗粒对复合水凝胶的微观结构有影响，并形成尺寸为 0.5 至 2 µm 的缔合物，附着在 PVP 水凝胶孔壁上。 PVP 和 TN/PVP 水凝胶表现出高度的水溶胀性。此外，与 PVP 水凝胶相比，TN/PVP 中二氧化钛纳米粒子的存在增加了水吸附循环次数。 NT/PVP 水凝胶具有高溶胀度、抗菌和抗金黄色葡萄球菌的抗菌特性，因此可以考虑将 NT/PVP 水凝胶作为伤口涂层用于医疗应用。