Alzheimer’s disease (AD) is a type of neurodegenerative malady that is associated with the accumulation of amyloid plaques. Metal ions are critical for the development and upkeep of brain activity, but metal dyshomeostasis can contribute to the development of neurodegenerative diseases, including AD. This review highlights the association between metal dyshomeostasis and AD pathology, the feasibility of rebalancing metal homeostasis as a therapeutic strategy for AD, and a survey of current drugs that action via rebalancing metal homeostasis. Finally, we discuss the challenges that should be overcome by researchers in the future to enable the practical use of metal homeostasis rebalancing agents for clinical application.

中文翻译：

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重新平衡金属异位症，用于阿尔茨海默氏病的治疗。

阿尔茨海默氏病（AD）是一种与淀粉样斑块积聚有关的神经退行性疾病。金属离子对于大脑活动的发展和维持至关重要，但是金属动态平衡会促进神经退行性疾病（包括AD）的发展。这篇综述着重介绍了金属动态平衡与AD病理学之间的关系，重新平衡金属动态平衡作为AD治疗策略的可行性以及对通过平衡金属动态平衡起作用的当前药物的调查。最后，我们讨论了未来的研究人员应克服的挑战，以使金属稳态平衡剂能够在临床应用中得到实际使用。