Phytochemistry Reviews ( IF 7.3 ) Pub Date : 2019-09-19 , DOI: 10.1007/s11101-019-09645-9 B M Gruessner 1 , L Cornet-Vernet 2 , M R Desrosiers 1 , P Lutgen 3 , M J Towler 1 , P J Weathers 1
Artemisia sp., especially A. annua and A. afra, have been used for centuries to treat many ailments. While artemisinin is the main therapeutically active component, emerging evidence demonstrates that the other phytochemicals in this genus are also therapeutically active. Those compounds include flavonoids, other terpenes, coumarins, and phenolic acids. Artemisia sp. phytochemicals also improve bioavailability of artemisinin and synergistically improve artemisinin therapeutic efficacy, especially when delivered as dried leaf Artemisia as a tea infusion or as powdered dry leaves in a capsule or compressed into a tablet. Here results from in vitro, and in vivo animal and human studies are summarized and critically discussed for mainly malaria, but also other diseases susceptible to artemisinin and Artemisia sp. including schistosomiasis, leishmaniasis, and trypanosomiasis.
中文翻译:
它不仅仅是青蒿素:Artemisia sp。用于治疗疟疾和血吸虫病等疾病
蒿属植物,尤其是青蒿和阿芙拉,几个世纪以来一直被用来治疗许多疾病。虽然青蒿素是主要的治疗活性成分,但新出现的证据表明该属的其他植物化学物质也具有治疗活性。这些化合物包括类黄酮、其他萜烯、香豆素和酚酸。蒿属植物化学物质还可以提高青蒿素的生物利用度,并协同提高青蒿素的治疗功效,特别是当以干叶形式作为茶浸液或以胶囊中的干叶粉末或压制成片剂形式提供时。这里总结并批判性地讨论了主要针对疟疾以及其他对青蒿素和蒿属敏感的疾病的体外和体内动物和人类研究的结果。包括血吸虫病、利什曼病和锥虫病。