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It is not just artemisinin: Artemisia sp. for treating diseases including malaria and schistosomiasis
Phytochemistry Reviews ( IF 7.7 ) Pub Date : 2019-09-19 , DOI: 10.1007/s11101-019-09645-9
B. M. Gruessner , L. Cornet-Vernet , M. R. Desrosiers , P. Lutgen , M. J. Towler , P. J. Weathers

Artemisia sp., especially A. annua and A. afra, have been used for centuries to treat many ailments. While artemisinin is the main therapeutically active component, emerging evidence demonstrates that the other phytochemicals in this genus are also therapeutically active. Those compounds include flavonoids, other terpenes, coumarins, and phenolic acids. Artemisia sp. phytochemicals also improve bioavailability of artemisinin and synergistically improve artemisinin therapeutic efficacy, especially when delivered as dried leaf Artemisia as a tea infusion or as powdered dry leaves in a capsule or compressed into a tablet. Here results from in vitro, and in vivo animal and human studies are summarized and critically discussed for mainly malaria, but also other diseases susceptible to artemisinin and Artemisia sp. including schistosomiasis, leishmaniasis, and trypanosomiasis.



中文翻译:

不仅仅是青蒿素:蒿属。用于治疗包括疟疾和血吸虫病在内的疾病

属,尤其是A. annuaA. afra,已经使用了多个世纪来治疗许多疾病。尽管青蒿素是主要的治疗活性成分,但新出现的证据表明该属中的其他植物化学物质也具有治疗活性。这些化合物包括类黄酮,其他萜烯,香豆素和酚酸。属 植物化学物质还可以提高青蒿素的生物利用度,并协同提高青蒿素的治疗功效,尤其是作为干叶青蒿叶提供时如泡茶或胶囊中的干粉粉末或压制成片剂。这里总结并批判性地讨论了主要针对疟疾以及其他易受青蒿素和青蒿菌感染的其他疾病的体外和体内动物和人体研究的结果,并进行了严格的讨论。包括血吸虫病,利什曼病和锥虫病。

更新日期:2019-09-19
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