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Midbrain hyperechogenicity, hyposmia, mild parkinsonian signs and risk for incident Parkinson's disease over 10 years: A prospective population-based study.
Parkinsonism & Related Disorders ( IF 3.1 ) Pub Date : 2019-12-11 , DOI: 10.1016/j.parkreldis.2019.12.008
Philipp Mahlknecht 1 , Heike Stockner 1 , Kathrin Marini 1 , Arno Gasperi 2 , Atbin Djamshidian 1 , Peter Willeit 3 , Stefan Kiechl 1 , Johann Willeit 1 , Gregorio Rungger 2 , Werner Poewe 1 , Klaus Seppi 1
Affiliation  

INTRODUCTION Associations of substantia nigra (SN) hyperechogenicity on transcranial sonography, olfactory dysfunction, and mild parkinsonian signs (MPS) with incident Parkinson's disease (PD) have only been studied over limited periods of follow-up and their long-term predictive properties are unclear. We aimed to prospectively assess the risk for incident PD over 10 years in community-dwelling elderly individuals with these risk markers. METHODS SN-hyperechogenicity, olfactory function, and MPS were assessed in the prospective population-based Bruneck Study (2005 in-person assessment; n = 574, aged 55-94 years). Cases of incident PD were identified at 5-year and 10-year follow-up visits. We estimated relative risks of baseline markers for incident cases. RESULTS After excluding 35 cases with PD or secondary parkinsonism at baseline, a total of 20 cases of incident PD were identified from the remaining 539 participants (11 at 5 years and 9 at 10 years). Relative risks for incident PD over the 10-year follow-up period were 7.43 (2.71-20.39), 3.60 (1.48-8.78), and 5.52 (2.43-12.57) for baseline SN-hyperechogenicity, hyposmia, and mild parkinsonian signs, respectively. While risk of hyposmia for incident PD was similar for the two sequential 5-year periods studied, relative risks of SN-hyperechogenicity and MPS were higher for the first five years as compared to later. CONCLUSION Our findings extend the established risk relationship of SN-hyperechogenicity, hyposmia, and MPS with incident PD beyond 5 years of follow-up.

中文翻译:

一项基于人群的前瞻性研究:中脑高回声性,低渗,轻度帕金森征象和10年内发生帕金森氏病的风险。

引言黑质(SN)超回声与经颅超声检查,嗅觉功能障碍和轻度帕金森病征(MPS)与帕金森病(PD)的关联仅在有限的随访期内进行了研究,其长期预测特性尚不清楚。我们旨在前瞻性评估具有这些风险标记的社区居民老年人在10年内发生PD的风险。方法在前瞻性人群布鲁内克研究(2005年面对面评估; n = 574,年龄55-94岁)中评估SN的超强回声性,嗅觉功能和MPS。在5年和10年的随访中发现了PD事件。我们估计了事件案例基线标记的相对风险。结果在排除基线时有35例PD或继发性帕金森病的患者后,从剩余的539名参与者中识别出总共20例PD事件(5岁时11例,10岁时9例)。在10年的随访期内,发生PD的相对危险性分别为基线SN超高致性,低渗和轻度帕金森病征象,分别为7.43(2.71-20.39),3.60(1.48-8.78)和5.52(2.43-12.57)。 。虽然连续两个5年研究期间发生PD的低渗风险相似,但前五年的SN超强回生性和MPS相对风险较高,而后来较高。结论我们的发现将随访5年以上的SN超高致畸性,低渗症和MPS与PD的风险建立了关系。在10年的随访期内,发生PD的相对危险性分别为基线SN超高致性,低渗和轻度帕金森病征象,分别为7.43(2.71-20.39),3.60(1.48-8.78)和5.52(2.43-12.57)。 。虽然连续两个5年研究期间发生PD的低渗风险相似,但前五年的SN超强回生性和MPS相对风险较高,而后来较高。结论我们的发现将随访5年以上的SN超高致畸性,低渗症和MPS与PD的风险建立了关系。在10年的随访期内,发生PD的相对风险分别为基线SN超高致性,低渗和轻度帕金森病征象的7.43(2.71-20.39),3.60(1.48-8.78)和5.52(2.43-12.57)。 。虽然连续两个5年研究期间发生PD的低渗风险相似,但前五年的SN超强回生性和MPS相对风险较高,而后来较高。结论我们的发现将随访5年以上的SN超高致畸性,低渗症和MPS与PD的风险建立了关系。前五年,SN超强生性和MPS的相对风险较高。结论我们的发现将随访5年以上的SN超高致畸性,低渗症和MPS与PD的风险建立了关系。前五年,SN超强生性和MPS的相对风险较高。结论我们的发现将随访5年以上的SN超高致畸性,低渗症和MPS与PD的风险建立了关系。
更新日期:2019-12-11
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