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Phenotypic features of vascular calcification in chronic kidney disease.
Journal of Internal Medicine ( IF 9.0 ) Pub Date : 2019-12-10 , DOI: 10.1111/joim.13012 L Dai 1 , M Debowska 2 , T Lukaszuk 3 , L Bobrowski 2, 3 , P Barany 1 , M Söderberg 4 , D Thiagarajan 5 , J Frostegård 5 , L Wennberg 6 , B Lindholm 1 , A R Qureshi 1 , J Waniewski 2 , P Stenvinkel 1
Journal of Internal Medicine ( IF 9.0 ) Pub Date : 2019-12-10 , DOI: 10.1111/joim.13012 L Dai 1 , M Debowska 2 , T Lukaszuk 3 , L Bobrowski 2, 3 , P Barany 1 , M Söderberg 4 , D Thiagarajan 5 , J Frostegård 5 , L Wennberg 6 , B Lindholm 1 , A R Qureshi 1 , J Waniewski 2 , P Stenvinkel 1
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BACKGROUND
Patients with chronic kidney disease stage 5 (CKD5) are predisposed to vascular calcification (VC), but the combined effect of factors associated with VC was sparsely investigated. We applied the relaxed linear separability (RLS) feature selection model to identify features that concomitantly associate with VC in CKD5 patients.
METHODS
Epigastric arteries collected during surgery from living donor kidney transplant recipients were examined to score the histological extent of medial VC. Sixty-two phenotypic features in 152 patients were entered into RLS model to differentiate between no-minimal VC (n = 93; score 0-1) and moderate-extensive VC (n = 59; score 2-3). The subset of features associated with VC was selected on the basis of cross-validation procedure. The strength of association of the selected features with VC was expressed by the absolute value of 'RLS factor'.
RESULTS
Among 62 features, a subset of 17 features provided optimal prediction of VC with 89% of patients correctly classified into their groups. The 17 features included traditional risk factors (diabetes, age, cholesterol, BMI and male sex) and markers of bone metabolism, endothelial function, metabolites, serum antibodies and mitochondrial-derived peptide. Positive RLS factors range from 1.26 to 4.05 indicating features associated with increased risk of VC, and negative RLS factors range from -0.95 to -1.83 indicating features associated with reduced risk of VC.
CONCLUSION
The RLS model identified 17 features including novel biomarkers and traditional risk factors that together concomitantly associated with medial VC. These results may inform further investigations of factors promoting VC in CKD5 patients.
中文翻译：
慢性肾脏疾病中血管钙化的表型特征。
背景技术患有慢性肾脏疾病5期（CKD5）的患者易患血管钙化（VC），但稀疏研究了与VC相关的因素的综合作用。我们应用了宽松的线性可分离性（RLS）特征选择模型来识别与CKD5患者的VC相伴的特征。方法检查从活体供体肾脏移植受者手术期间收集的上腹动脉，以评分内侧VC的组织学程度。将152例患者的62个表型特征输入RLS模型，以区分无最小VC（n = 93；得分0-1）和中度扩张VC（n = 59；得分2-3）。根据交叉验证程序选择了与VC相关的功能的子集。所选特征与VC关联的强度由“ RLS因子”的绝对值表示。结果在62个特征中，有17个特征的子集提供了VC的最佳预测，其中89％的患者正确分类。这17个特征包括传统的危险因素（糖尿病，年龄，胆固醇，BMI和男性性别）以及骨代谢，内皮功能，代谢产物，血清抗体和线粒体衍生肽的标志物。正的RLS因子范围从1.26到4.05，指示与VC风险增加相关的特征，而负的RLS因子范围从-0.95至-1.83，指示与VC风险降低相关的特征。结论RLS模型确定了17种特征，包括新颖的生物标志物和传统的危险因素，这些特征与VC伴发。
更新日期：2019-12-10
中文翻译：
慢性肾脏疾病中血管钙化的表型特征。
背景技术患有慢性肾脏疾病5期（CKD5）的患者易患血管钙化（VC），但稀疏研究了与VC相关的因素的综合作用。我们应用了宽松的线性可分离性（RLS）特征选择模型来识别与CKD5患者的VC相伴的特征。方法检查从活体供体肾脏移植受者手术期间收集的上腹动脉，以评分内侧VC的组织学程度。将152例患者的62个表型特征输入RLS模型，以区分无最小VC（n = 93；得分0-1）和中度扩张VC（n = 59；得分2-3）。根据交叉验证程序选择了与VC相关的功能的子集。所选特征与VC关联的强度由“ RLS因子”的绝对值表示。结果在62个特征中，有17个特征的子集提供了VC的最佳预测，其中89％的患者正确分类。这17个特征包括传统的危险因素（糖尿病，年龄，胆固醇，BMI和男性性别）以及骨代谢，内皮功能，代谢产物，血清抗体和线粒体衍生肽的标志物。正的RLS因子范围从1.26到4.05，指示与VC风险增加相关的特征，而负的RLS因子范围从-0.95至-1.83，指示与VC风险降低相关的特征。结论RLS模型确定了17种特征，包括新颖的生物标志物和传统的危险因素，这些特征与VC伴发。
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