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Tough hydrogel module towards an implantable remote and controlled release device.
Biomaterials Science ( IF 5.8 ) Pub Date : 2019-12-17 , DOI: 10.1039/c9bm01882d Zhi Wei Kenny Low 1 , Yifei Luo , Kangyi Zhang , Qianyu Lin , Cally Owh , Xiaodong Chen , Xian Jun Loh
Biomaterials Science ( IF 5.8 ) Pub Date : 2019-12-17 , DOI: 10.1039/c9bm01882d Zhi Wei Kenny Low 1 , Yifei Luo , Kangyi Zhang , Qianyu Lin , Cally Owh , Xiaodong Chen , Xian Jun Loh
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On-demand controllable drug delivery systems enable the administration of precise dosages and thus have the potential to improve overall healthcare. In this work, a tough physical hydrogel is developed and studied for triggered burst release. Semicrystalline poly (vinyl alcohol) (PVA) is combined with ionic pectin (CaP) to form an interpenetrating network (PVA-CaP). The synergistic combination of crosslinking mechanisms resulted in a threefold improvement in tensile modulus and fracture energy over pristine PVA. As a result of the physical network, crosslink dissociation could be induced by heating. This trait is used as a trigger for burst release of a payload in PVA-CaP flexible substrates. Highly localized and on-demand burst release can be effectively achieved through the inclusion of electronic devices. Cell adhesion and viability tests show that the addition of pectin remarkably improves cell attachment ability and provides a favourable environment for cell proliferation. Implantation tests finally show the suitability of the material for implantation and its ability to conform with natural tissue. Such a system is envisioned for use as an implantable remote and controlled release device.
中文翻译：
坚韧的水凝胶模块朝向可植入的遥控释放装置。
按需可控的药物输送系统使精确剂量的给药成为可能，因此具有改善整体医疗保健的潜力。在这项工作中，开发了一种坚韧的物理水凝胶，并对其进行了触发释放的研究。半结晶聚乙烯醇（PVA）与离子果胶（CaP）结合形成互穿网络（PVA-CaP）。交联机理的协同组合使拉伸模量和断裂能比原始PVA提高了三倍。作为物理网络的结果，可以通过加热来引起交联解离。该特性用作触发PVA-CaP柔性基板中有效负载的突然释放的触发因素。通过包含电子设备，可以有效实现高度本地化和按需的突发释放。细胞粘附力和生存力测试表明，添加果胶可显着提高细胞附着能力，并为细胞增殖提供良好的环境。植入测试最终表明该材料适合植入，并具有与天然组织相适应的能力。设想将这样的系统用作可植入的远程和受控释放装置。
更新日期：2020-02-13
中文翻译：
坚韧的水凝胶模块朝向可植入的遥控释放装置。
按需可控的药物输送系统使精确剂量的给药成为可能，因此具有改善整体医疗保健的潜力。在这项工作中，开发了一种坚韧的物理水凝胶，并对其进行了触发释放的研究。半结晶聚乙烯醇（PVA）与离子果胶（CaP）结合形成互穿网络（PVA-CaP）。交联机理的协同组合使拉伸模量和断裂能比原始PVA提高了三倍。作为物理网络的结果，可以通过加热来引起交联解离。该特性用作触发PVA-CaP柔性基板中有效负载的突然释放的触发因素。通过包含电子设备，可以有效实现高度本地化和按需的突发释放。细胞粘附力和生存力测试表明，添加果胶可显着提高细胞附着能力，并为细胞增殖提供良好的环境。植入测试最终表明该材料适合植入，并具有与天然组织相适应的能力。设想将这样的系统用作可植入的远程和受控释放装置。
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