BACKGROUND To determine the repeatability of measurements of ocular surface vessel density in normal and diseased eyes using optical coherence tomography angiography (OCTA). METHODS Ten normal eyes, 10 pinguecula eyes, and 10 pterygium eyes of 30 volunteers were subjected to OCTA (AngioVue Imaging System, Optovue, Inc.). For scanning, we used the corneal adapter module. Each eye was scanned three times in the nasal and temporal directions, separately. AngioVue software was used to generate the ocular surface vessel density. Ocular surface vessel density was defined as the proportion of vessel area with blood flow to the total measurement area (3 × 3 mm2). Intersession repeatability of the measurement was summarized as the coefficient of variation (CV), and intraclass correlation coefficients (ICC) were calculated by variance component models. RESULTS The CVs were less than 5% in all subjects, and the ICCs exceeded 0.9; thus, all measurements showed good repeatability. The nasal vessels densities differed significantly between healthy eyes and eyes with pterygium (P < 0.05); however, there was no significant difference between healthy eyes and eyes with pinguecula (P = 0.466). CONCLUSIONS These results suggest that measurement of ocular surface vessel density by OCTA in normal eyes and eyes with pterygium and pinguecula is repeatable. This preliminary research describes a quantitative and visual method for assessing vessel density of the ocular surface with a high level of consistency.

中文翻译：

---

用光学相干断层扫描血管造影术测量眼表血管密度的可重复性。

背景技术为了确定使用光学相干断层扫描血管造影术（OCTA）在正常和患病眼中测量眼表血管密度的可重复性。方法对30名志愿者的10只正常眼，10只针状眼和翼状肉眼进行OCTA（AngioVue成像系统，Optovue，Inc。）。为了进行扫描，我们使用了角膜适配器模块。每只眼睛分别在鼻和颞方向扫描三遍。AngioVue软件用于生成眼表血管密度。眼表血管密度定义为血管面积与血流的比重占总测量面积的比例（3×3 mm2）。会话间测量的可重复性总结为变异系数（CV），并通过方差分量模型计算组内相关系数（ICC）。结果所有受试者的CV均低于5％，ICC超过0.9；因此，所有测量结果均显示出良好的可重复性。健康眼和翼状eyes肉眼的鼻腔血管密度存在显着差异（P <0.05）。但是，健康的眼睛和患有针状眼的眼睛之间没有显着差异（P = 0.466）。结论这些结果表明，通过OCTA在正常眼和翼状and肉和针状eyes眼中测量眼表血管密度是可重复的。这项初步研究描述了一种定量和视觉方法，可以高度一致性地评估眼表的血管密度。健康眼和翼状eyes肉眼的鼻腔血管密度存在显着差异（P <0.05）。但是，健康的眼睛和患有针状眼的眼睛之间没有显着差异（P = 0.466）。结论这些结果表明，通过OCTA在正常眼和翼状and肉和针状eyes眼中测量眼表血管密度是可重复的。这项初步研究描述了一种定量和视觉方法，可以高度一致性地评估眼表的血管密度。健康眼和翼状eyes肉眼的鼻腔血管密度存在显着差异（P <0.05）。但是，健康的眼睛和患有针状眼的眼睛之间没有显着差异（P = 0.466）。结论这些结果表明，通过OCTA对正常眼和翼状and肉和针状眼的眼睛进行眼表血管密度测量是可重复的。这项初步研究描述了一种定量和视觉方法，可以高度一致性地评估眼表的血管密度。