BACKGROUND The deficiency of vitamin D receptor (VDR) or its ligand, vitamin D3, is linked to the development of renal diseases. The TaqI (rs731236) and ApaI (rs7975232) polymorphisms of VDR gene are widely studied for their association with renal disease risk. However, studies have largely been ambiguous. METHODS Meta-analysis was carried out to clarify the association of TaqI (2777 cases and 3522 controls) and ApaI (2440 cases and 3279 controls) polymorphisms with nephrolithiasis (NL), diabetic nephropathy (DN) and end stage renal disease (ESRD). RESULTS The VDR TaqI C-allele under allele contrast was significantly associated with ESRD in both fixed effect and random effect models, and ApaI C-allele with ESRD only under fixed effect model. Cochrane Q-test showed no evidence of heterogeneity for TaqI polymorphism and a significant heterogeneity for Apa I polymorphism. No publication bias was observed for both the polymorphisms. CONCLUSIONS The present meta-analysis identifies TaqI and ApaI polymorphisms of VDR gene as risk factors for renal diseases.

中文翻译：

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维生素D受体TaqI和ApaI基因多态性与肾结石和终末期肾脏疾病的关联：一项荟萃分析。

背景技术维生素D受体（VDR）或其配体维生素D3的缺乏与肾脏疾病的发展有关。广泛研究了VDR基因的TaqI（rs731236）和ApaI（rs7975232）多态性与肾脏疾病风险的关系。然而，研究很大程度上是模棱两可的。方法进行荟萃分析以阐明TaqI（2777例和3522对照）和ApaI（2440例和3279对照）多态性​​与肾结石病（NL），糖尿病肾病（DN）和终末期肾病（ESRD）的相关性。结果在固定效应和随机效应模型中，等位基因对比下的VDR TaqI C等位基因均与ESRD显着相关，而在固定效应模型下，具有ESRD的ApaI C等位基因仅与ESRD相关。Cochrane Q检验显示TaqI多态性没有异质性，Apa I多态性也无明显异质性。两种多态性均未观察到发表偏倚。结论本荟萃分析确定了VDR基因的TaqI和ApaI多态性是肾病的危险因素。