To describe the association of age, sex and body mass index with the rate of change of tibial knee cartilage volume over 10.7 years in a community-based sample of older adults. Four hundred and eighty-one participants (49% female, mean age 60.8 years [range 51.1–79.7], 49% had knee pain and 58% radiographic osteoarthritis) were included. Tibial cartilage volume of the right knee was assessed on T1-weighted fat-suppressed 1.5 T MRI at baseline and 10.7 years. Data analyses were performed using linear regression models. The average rate of loss of cartilage volume was 1.2%/year (range 0.2–3.9%) with all participants losing cartilage volume over the study period. There was a significant association between age and loss of tibial cartilage volume in the medial (0.023%/year, 95% confidence interval [CI] 0.010 to 0.036%, p < 0.001), lateral (0.013%/year, 95% CI 0.003 to 0.023%, p = 0.012) and total tibia (0.018%/year, 95% CI 0.009 to 0.026%, p < 0.001). Higher body mass index at baseline and increases in body mass index over time were associated with a greater tibial cartilage loss at the medial (body mass index at baseline 0.040%/year, 95% CI 0.022 to 0.058%, p < 0.001; increases in body mass index 0.055%/year, 95% CI 0.018 to 0.093%, p = 0.004) but not lateral compartment. No evidence of non-linear relationships was observed. Compared to males, females lost more lateral tibial cartilage with increasing age (0.023%/year, 95% CI 0.003 to 0.043%, p = 0.024 for interaction). Tibial cartilage volume declines at a faster rate with increasing age and body mass index in both males and females, particularly in the medial compartment. In contrast to the low rate of change in radiographs, our findings suggest that cartilage loss at the tibia is universal in this age group.

中文翻译：

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年龄，性别和BMI与胫骨软骨体积变化率的关联：一项为期10.7年的纵向队列研究。

在以社区为基础的老年人样本中，描述年龄，性别和体重指数与胫骨膝关节软骨体积变化率超过10.7年的关系。包括481名参与者（女性占49％，平均年龄60.8岁[范围51.1-79.7]，膝关节疼痛占49％，放射影像学上的骨关节炎占58％）。在基线和10.7年时，通过T1加权脂肪抑制的1.5 T MRI评估右膝的胫骨软骨体积。使用线性回归模型进行数据分析。软骨体积的平均丧失率为1.2％/年（范围为0.2–3.9％），所有参与者在研究期间丧失软骨体积。年龄与内侧胫骨软骨体积减少之间存在显着关联（0.023％/年，95％置信区间[CI] 0.010至0.036％，p <0.001），外侧（0。013％/年，95％CI为0.003至0.023％，p = 0.012）和总胫骨（0.018％/年，95％CI为0.009至0.026％，p <0.001）。基线时较高的体重指数和随时间推移而增加的体重指数与内侧胫骨软骨损失更大有关（基线时的体重指数为0.040％/年，95％CI为0.022至0.058％，p <0.001；体重指数0.055％/年，95％CI 0.018至0.093％，p = 0.004），但不包括侧室。没有观察到非线性关系的证据。与雄性相比，雌性随着年龄的增长损失了更多的胫骨外侧软骨（0.023％/年，95％CI为0.003至0.043％，交互作用p = 0.024）。男性和女性，尤其是内侧隔室，随着年龄和体重指数的增加，胫骨软骨体积下降的速度更快。与射线照片变化率低相比，