Alaska Native (AN) people experience higher incidence of, and mortality from, gastric cancer compared to other U.S. populations^{1, 2}. Compared to the general U.S. population, gastric cancer in AN people occurs at a younger age, is diagnosed at later stages, is more evenly distributed between the sexes, and is more frequently signet-ring or diffuse histology³. It is known that the prevalence of Helicobacter pylori (Hp) infection, a risk factor for gastric cancer, is high in AN people⁴; however, high antimicrobial resistance combined with high reinfection rates in Alaska make treatment at the population level complex⁵. In addition, health issues in AN people are uniquely challenging due to the extremely remote locations of many residents.

A multiagency workgroup hosted a symposium in Anchorage that brought internationally-recognized experts and local leaders together to evaluate issues around gastric cancer in the AN population. The overall goal of this symposium was to identify the best strategies to combat gastric cancer in the AN population through prevention and early diagnosis.

与美国其他人群相比，阿拉斯加原住民 (AN) 的胃癌发病率和死亡率更高^{1, 2} 。与美国普通人群相比，AN 人群的胃癌发病年龄较轻，诊断较晚，性别分布更均匀，组织学上更常见为印戒型或弥漫性³ 。众所周知，幽门螺杆菌( Hp ) 感染（胃癌的危险因素）在 AN 人群中的患病率很高⁴ ；然而，阿拉斯加的高抗菌药物耐药性加上高再感染率使得人口层面的治疗变得复杂⁵ 。此外，由于许多居民居住地极其偏远，AN 人群的健康问题具有独特的挑战性。

一个多机构工作组在安克雷奇主办了一次研讨会，国际知名专家和当地领导人齐聚一堂，评估与 AN 人群胃癌相关的问题。本次研讨会的总体目标是通过预防和早期诊断确定对抗 AN 人群胃癌的最佳策略。