Efferocytosis in health and disease.,Nature Reviews Immunology

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Efferocytosis in health and disease.
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2019-12-10 , DOI: 10.1038/s41577-019-0240-6
Amanda C Doran _{1,

2,

3} , Arif Yurdagul ₄ , Ira Tabas _{4,

5,

6}

Affiliation

The clearance of apoptotic cells by professional and non-professional phagocytes - a process termed 'efferocytosis' - is essential for the maintenance of tissue homeostasis. Accordingly, defective efferocytosis underlies a growing list of chronic inflammatory diseases. Although much has been learnt about the mechanisms of apoptotic cell recognition and uptake, several key areas remain incompletely understood. This Review focuses on new discoveries related to how phagocytes process the metabolic cargo they receive during apoptotic cell uptake; the links between efferocytosis and the resolution of inflammation in health and disease; and the roles of efferocytosis in host defence. Understanding these aspects of efferocytosis sheds light on key physiological and pathophysiological processes and suggests novel therapeutic strategies for diseases driven by defective efferocytosis and impaired inflammation resolution.

中文翻译：

健康和疾病中的红细胞增多症。

专业和非专业吞噬细胞清除凋亡细胞的过程（称为“胞吞作用”）对于维持组织稳态是必不可少的。因此，有缺陷的红细胞增多症是越来越多的慢性炎性疾病的基础。尽管已经了解了许多有关凋亡细胞识别和摄取机制的知识，但仍未完全理解几个关键领域。这篇综述着重于吞噬细胞如何处理凋亡细胞摄取过程中所接收的代谢产物相关的新发现。在健康和疾病中，红细胞增多症与炎症消退之间的联系；以及胞吞作用在宿主防御中的作用。

更新日期：2019-12-11

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