Energy metabolism manipulates the fate and function of tumour myeloid-derived suppressor cells.,British Journal of Cancer

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Energy metabolism manipulates the fate and function of tumour myeloid-derived suppressor cells.
British Journal of Cancer ( IF 6.4 ) Pub Date : 2019-12-10 , DOI: 10.1038/s41416-019-0644-x
Cong Hu _{1,

2,

3} , Bo Pang _{1,

4} , Guangzhu Lin ₄ , Yu Zhen ₅ , Huanfa Yi _{1,

2}

Affiliation

In recent years, a large number of studies have been carried out in the field of immune metabolism, highlighting the role of metabolic energy reprogramming in altering the function of immune cells. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells generated during a large array of pathological conditions, such as cancer, inflammation, and infection, and show remarkable ability to suppress T-cell responses. These cells can also change their metabolic pathways in response to various pathogen-derived or inflammatory signals. In this review, we focus on the roles of glucose, fatty acid (FA), and amino acid (AA) metabolism in the differentiation and function of MDSCs in the tumour microenvironment, highlighting their potential as targets to inhibit tumour growth and enhance tumour immune surveillance by the host. We further highlight the remaining gaps in knowledge concerning the mechanisms determining the plasticity of MDSCs in different environments and their specific responses in the tumour environment. Therefore, this review should motivate further research in the field of metabolomics to identify the metabolic pathways driving the enhancement of MDSCs in order to effectively target their ability to promote tumour development and progression.

中文翻译：

能量代谢操纵肿瘤骨髓源性抑制细胞的命运和功能。

近年来，免疫代谢领域开展了大量研究，强调了代谢能量重编程在改变免疫细胞功能中的作用。骨髓源性抑制细胞 (MDSC) 是在癌症、炎症和感染等多种病理条件下产生的异质细胞群，并表现出显着的抑制 T 细胞反应的能力。这些细胞还可以改变其代谢途径以响应各种病原体来源或炎症信号。在这篇综述中，我们重点关注肿瘤微环境中葡萄糖、脂肪酸（FA）和氨基酸（AA）代谢在MDSC分化和功能中的作用，强调它们作为抑制肿瘤生长和增强肿瘤免疫的靶点的潜力受到宿主的监视。我们进一步强调了关于决定 MDSC 在不同环境中的可塑性的机制及其在肿瘤环境中的特定反应的知识空白。因此，这篇综述应该激发代谢组学领域的进一步研究，以确定驱动MDSCs增强的代谢途径，从而有效地靶向其促进肿瘤发生和进展的能力。

更新日期：2019-12-11

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