Window of opportunity clinical trial designs to study cancer metabolism.,British Journal of Cancer

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Window of opportunity clinical trial designs to study cancer metabolism.
British Journal of Cancer ( IF 6.4 ) Pub Date : 2019-12-10 , DOI: 10.1038/s41416-019-0621-4
Francesca Aroldi ₁ , Simon R Lord ₁

Affiliation

Window of opportunity trials exploit the 'window' of time after cancer diagnosis, typically prior to initiation of cancer therapy. In recent years this study design has become a more regular feature of drug development, as this 'window' provides an opportunity to carry out a thorough pharmacodynamic assessment of a therapy of interest in tumours that are unperturbed by prior treatment. Many of the first window trials interrogated the bioactivity of drugs being repurposed for cancer treatment, in particular the anti-mitochondrial agent, metformin. In this review, we describe examples of window study designs that have been used to assess drugs that target cancer metabolism with a focus on metformin. In addition, we discuss how window studies may aid the development of molecular metabolic cancer imaging.

中文翻译：

研究癌症代谢的机会之窗临床试验设计。

机会窗口试验利用癌症诊断后的“时间窗口”，通常是在开始癌症治疗之前。近年来，这项研究设计已成为药物开发的一个更常规的特征，因为这个“窗口”提供了一个机会，可以对不受先前治疗干扰的肿瘤感兴趣的治疗进行彻底的药效学评估。许多第一个窗口试验询问了重新用于癌症治疗的药物的生物活性，特别是抗线粒体药物二甲双胍。在这篇综述中，我们描述了窗口研究设计的示例，这些设计已用于评估靶向癌症代谢的药物，重点是二甲双胍。此外，我们讨论了窗口研究如何有助于分子代谢癌症成像的发展。

更新日期：2019-12-11

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