Functional Nanoparticles with a Reducible Tetrasulfide Motif to Upregulate mRNA Translation and Enhance Transfection in Hard-to-Transfect Cells.,Angewandte Chemie International Edition

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Functional Nanoparticles with a Reducible Tetrasulfide Motif to Upregulate mRNA Translation and Enhance Transfection in Hard-to-Transfect Cells.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2019-12-09 , DOI: 10.1002/anie.201914264
Yue Wang ₁ , Jie Tang ₁ , Yannan Yang ₁ , Hao Song ₁ , Jianye Fu ₁ , Zhengying Gu ₁ , Chengzhong Yu ₁

Affiliation

Effective messenger RNA (mRNA) transfection in hard-to-transfect cells delivered by vectors is a long-standing challenge. Now it is hypothesized that the high intracellular glutathione level is associated with suppressed mRNA translation. This theory leads to a new design principle of next-generation mRNA vectors: nanoparticles with glutathione depletion chemistry upregulate mRNA translation and enhance transfection, which is beneficial for mRNA delivery in hard-to-transfect cells in vitro and in vivo.

中文翻译：

具有可还原的四硫键母体的功能性纳米颗粒，可上调mRNA的翻译并增强难以转染的细胞中的转染。

通过载体递送的难以转染的细胞中有效的信使RNA（mRNA）转染是一个长期的挑战。现在假设高的细胞内谷胱甘肽水平与抑制的mRNA翻译有关。该理论引发了下一代mRNA载体的新设计原理：具有谷胱甘肽耗减化学作用的纳米颗粒可上调mRNA的翻译并增强转染，这有利于在体内外难以转染的细胞中传递mRNA。

更新日期：2020-01-10

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