Metastasis is the leading cause of cancer mortality. Cancer cells must adapt to colonize and thrive at the metastatic site. The modulation of the receptive organ microenvironment is a key event in the adaptation process and is partially accomplished at a distance by the primary tumor. Exosomes, a subclass of extracellular vesicles (EVs), are distal mediators of communication that carry genetic and molecular information to neighboring and distant cells. Cancer exosomes have been involved in restructuring metastatic sites to support cancer cell colonization. In this article, we discuss the role of exosomes in the metastatic process.

中文翻译：

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解码转移中外泌体的生物学。

转移是癌症死亡的主要原因。癌细胞必须适应转移部位的集聚和生长。感受器官微环境的调节是适应过程中的关键事件，并在一定距离内由原发肿瘤部分完成。外泌体是细胞外囊泡（EVs）的一个子类，是将遗传和分子信息携带到邻近和远处的细胞的通信的远端介质。癌症外来体已参与重组转移部位以支持癌细胞定植。在本文中，我们讨论了外泌体在转移过程中的作用。