In recent years was observed an increased interest towards the use of metal nanoparticles for various biomedical applications, such as therapeutics, delivery systems or imaging. As biological membranes are the first structures with which the nanoparticles interact, it is necessary to understand better the mechanisms governing these interactions. In the present paper we aim to characterize the effect of three different ferrihydrite nanoparticles (simple or doped with cooper or cobalt) on the fluidity of model lipid membranes. First we evaluated the physicochemical properties of the nanoparticles: size and composition. Secondly, their effect on lipid membranes was also evaluated using Laurdan, TMA-DPH and DPH fluorescence. Our results can help better understand the mechanisms involved in nanoparticles and membrane interactions.

中文翻译：

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水铁矿纳米粒子与模型脂质膜的相互作用。

近年来，人们观察到对金属纳米颗粒用于各种生物医学应用（例如治疗，递送系统或成像）的兴趣日益增加。由于生物膜是与纳米颗粒相互作用的第一结构，因此有必要更好地了解控制这些相互作用的机理。在本文中，我们旨在表征三种不同的水铁矿纳米粒子（简单或掺有铜或钴）对模型脂质膜流动性的影响。首先，我们评估了纳米粒子的物理化学性质：大小和组成。其次，还使用Laurdan，TMA-DPH和DPH荧光评估了它们对脂质膜的作用。我们的结果可以帮助更好地了解纳米颗粒和膜相互作用中涉及的机制。