当前位置：
X-MOL 学术
›
Food Chem. Toxicol.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Anti-fatigue effect of aqueous extract of Hechong (Tylorrhynchus heterochaetus) via AMPK linked pathway.
Food and Chemical Toxicology ( IF 3.9 ) Pub Date : 2019-12-10 , DOI: 10.1016/j.fct.2019.111043 Ziqing Yang 1 , Christudas Sunil 1 , Muthukumaran Jayachandran 2 , Xuchu Zheng 3 , Kuopeng Cui 3 , Yuepeng Su 3 , Baojun Xu 1
Food and Chemical Toxicology ( IF 3.9 ) Pub Date : 2019-12-10 , DOI: 10.1016/j.fct.2019.111043 Ziqing Yang 1 , Christudas Sunil 1 , Muthukumaran Jayachandran 2 , Xuchu Zheng 3 , Kuopeng Cui 3 , Yuepeng Su 3 , Baojun Xu 1
Affiliation
|
Tylorrhynchus heterochaetus (Hechong in Chinese) has been used in Chinese traditional medicine for treating various diseases. This study was aimed to assess the anti-fatigue effect of T. heterochaetus on Kunming mice and its primary mechanism of action using forced running, rotating rod and weight-loaded swimming tests. Low (2.70 mg/0.5 mL/20 g), medium (5.41 mg/0.5 mL/20 g) and high (6.58 mg/0.5 mL/20 g) doses of T. heterochaetus aqueous extract were treated to mice for 28 days. Among the doses, the low and medium doses showed significant (p ≤ 0.05) anti-fatigue effect on the weight-loaded swimming test. Also, T. heterochaetus extract showed significant (p ≤ 0.05) effects on fatigue-related blood parameters by increasing the GLU, TG and LDH levels and decreasing the LA, CK and BUN levels. The levels of liver and skeletal muscle glycogen were also significantly (p ≤ 0.05) increased after treatment. Further, on Western blot analysis, it has been found that T. heterochaetus enhanced the expressions of AMPK and PGC-1α in the liver and skeletal muscles of mice. From the study, our outcomes suggest that T. heterochaetus possess an anti-fatigue effect through the AMPK-linked pathway and thereby it can regularize the energy metabolism.
中文翻译：
通过AMPK连锁途径的合冲含水提取物的抗疲劳作用。
香根草（Hechong）已被用于中药治疗各种疾病。这项研究旨在通过强迫跑步，旋转杆和负重游泳试验评估异花苜蓿对昆明小鼠的抗疲劳作用及其主要作用机理。将低剂量（2.70 mg / 0.5 mL / 20 g），中等剂量（5.41 mg / 0.5 mL / 20 g）和高剂量（6.58 mg / 0.5 mL / 20 g）的异花苜蓿含水提取物对小鼠处理28天。在这些剂量中，低剂量和中等剂量对负重游泳试验显示出显着的（p≤0.05）抗疲劳作用。此外，异花T草提取物通过增加GLU，TG和LDH水平并降低LA，CK和BUN水平，对疲劳相关的血液参数显示出显着（p≤0.05）影响。治疗后肝和骨骼肌糖原水平也显着增加（p≤0.05）。此外，在Western印迹分析中，已经发现异翅目T.chachatusus增强了小鼠的肝脏和骨骼肌中AMPK和PGC-1α的表达。从这项研究中，我们的结果表明，异花苜蓿通过AMPK连锁途径具有抗疲劳作用，因此可以调节能量代谢。
更新日期：2019-12-11
中文翻译：
通过AMPK连锁途径的合冲含水提取物的抗疲劳作用。
香根草（Hechong）已被用于中药治疗各种疾病。这项研究旨在通过强迫跑步，旋转杆和负重游泳试验评估异花苜蓿对昆明小鼠的抗疲劳作用及其主要作用机理。将低剂量（2.70 mg / 0.5 mL / 20 g），中等剂量（5.41 mg / 0.5 mL / 20 g）和高剂量（6.58 mg / 0.5 mL / 20 g）的异花苜蓿含水提取物对小鼠处理28天。在这些剂量中，低剂量和中等剂量对负重游泳试验显示出显着的（p≤0.05）抗疲劳作用。此外，异花T草提取物通过增加GLU，TG和LDH水平并降低LA，CK和BUN水平，对疲劳相关的血液参数显示出显着（p≤0.05）影响。治疗后肝和骨骼肌糖原水平也显着增加（p≤0.05）。此外，在Western印迹分析中，已经发现异翅目T.chachatusus增强了小鼠的肝脏和骨骼肌中AMPK和PGC-1α的表达。从这项研究中，我们的结果表明，异花苜蓿通过AMPK连锁途径具有抗疲劳作用，因此可以调节能量代谢。
京公网安备 11010802027423号