Cardiotoxicity and nephrotoxicity due to the abnormal production of free radicals have been observed in patients treated with the anticancer antibiotic adriamycin (ADR). The aim of the present study was to evaluate the role of the heart of palm extract in preventing oxidative stress, cardiotoxicity and nephrotoxicity induced by ADR. In this work, an aqueous ethanolic extract of the heart of the Phoenix dactylifera tree (HP) was investigated. The polyphenol content was evaluated by gas chromatography-mass spectrometry (GC-MS) and High-performance liquid chromatography (HPLC). The protective effect of the HP-extract (250 and 500 mg/kg, p.o.) was evaluated along with ADR administration (cumulative dose 15 mg/kg, IP) in rats. The HP-extract (500 mg/kg) treated group showed significant reductions in cardiotoxicity and nephrotoxicity serum markers, apoptotic percentage, and caspase-3 and cyclooxygenase-2 level, with an improvement in antioxidant enzymes in both heart and kidney homogenate, compared with the ADR-induction group. The cardiac and kidney programmed cell death protein-1 (PD-1) was increased in high dose HP-extract treated rats after being inhibited by ADR administration. In conclusion, the HP-extract might be a promising food supplement for preventing the cardiotoxicity and nephrotoxicity induced by ADR administration.

中文翻译：

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通过调节细胞凋亡，氧化应激和PD-1抑制，凤凰果树心提取物对阿霉素诱导的心脏毒性和肾毒性的化学保护作用。

在用抗癌抗生素阿霉素（ADR）治疗的患者中，观察到由于自由基异常产生而引起的心脏毒性和肾毒性。本研究的目的是评估棕榈提取物心脏在预防ADR引起的氧化应激，心脏毒性和肾毒性中的作用。在这项工作中，研究了凤凰果树（HP）心脏的乙醇提取液。通过气相色谱-质谱法（GC-MS）和高效液相色谱法（HPLC）评估多酚含量。评估了HP提取物（250和500 mg / kg，口服）的保护作用以及ADR的给药（累积剂量15 mg / kg，IP）对大鼠的保护作用。HP提取物（500 mg / kg）治疗组的心脏毒性和肾毒性血清标志物明显降低，与ADR诱导组相比，细胞凋亡百分比以及caspase-3和环氧合酶2水平的升高，心脏和肾脏匀浆中的抗氧化酶均得到改善。在高剂量HP提取物处理的大鼠中，心脏和肾脏程序性细胞死亡蛋白1（PD-1）受ADR抑制后增加。总之，HP提取物可能是预防ADR引起的心脏毒性和肾毒性的有前途的食品补充剂。