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Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification.
Bone Research ( IF 14.3 ) Pub Date : 2019-12-10 , DOI: 10.1038/s41413-019-0075-6 Charles Hwang 1 , Simone Marini 1, 2 , Amanda K Huber 1 , David M Stepien 1 , Michael Sorkin 1 , Shawn Loder 1 , Chase A Pagani 1 , John Li 1 , Noelle D Visser 1 , Kaetlin Vasquez 1 , Mohamed A Garada 1 , Shuli Li 1 , Jiajia Xu 3 , Ching-Yun Hsu 3 , Paul B Yu 4 , Aaron W James 3 , Yuji Mishina 5 , Shailesh Agarwal 1 , Jun Li 2 , Benjamin Levi 1
Bone Research ( IF 14.3 ) Pub Date : 2019-12-10 , DOI: 10.1038/s41413-019-0075-6 Charles Hwang 1 , Simone Marini 1, 2 , Amanda K Huber 1 , David M Stepien 1 , Michael Sorkin 1 , Shawn Loder 1 , Chase A Pagani 1 , John Li 1 , Noelle D Visser 1 , Kaetlin Vasquez 1 , Mohamed A Garada 1 , Shuli Li 1 , Jiajia Xu 3 , Ching-Yun Hsu 3 , Paul B Yu 4 , Aaron W James 3 , Yuji Mishina 5 , Shailesh Agarwal 1 , Jun Li 2 , Benjamin Levi 1
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Heterotopic ossification (HO) is a debilitating condition characterized by the pathologic formation of ectopic bone. HO occurs commonly following orthopedic surgeries, burns, and neurologic injuries. While surgical excision may provide palliation, the procedure is often burdened with significant intra-operative blood loss due to a more robust contribution of blood supply to the pathologic bone than to native bone. Based on these clinical observations, we set out to examine the role of vascular signaling in HO. Vascular endothelial growth factor A (VEGFA) has previously been shown to be a crucial pro-angiogenic and pro-osteogenic cue during normal bone development and homeostasis. Our findings, using a validated mouse model of HO, demonstrate that HO lesions are highly vascular, and that VEGFA is critical to ectopic bone formation, despite lacking a contribution of endothelial cells within the developing anlagen.
中文翻译：
间充质 VEGFA 诱导异位骨化的异常分化。
异位骨化 (HO) 是一种使人衰弱的疾病，其特征是异位骨的病理形成。HO 通常发生在骨科手术、烧伤和神经损伤之后。虽然手术切除可以提供姑息治疗，但由于对病理骨的血液供应比对天然骨的贡献更大，因此手术通常会承受大量的术中失血。基于这些临床观察，我们着手研究血管信号在 H2O 中的作用。血管内皮生长因子 A (VEGFA) 先前已被证明是正常骨骼发育和体内平衡过程中关键的促血管生成和促骨生成线索。我们的研究结果，使用经过验证的 HO 小鼠模型，证明 HO 病变具有高度血管性，并且 VEGFA 对异位骨形成至关重要，
更新日期：2019-12-10
中文翻译：
间充质 VEGFA 诱导异位骨化的异常分化。
异位骨化 (HO) 是一种使人衰弱的疾病，其特征是异位骨的病理形成。HO 通常发生在骨科手术、烧伤和神经损伤之后。虽然手术切除可以提供姑息治疗，但由于对病理骨的血液供应比对天然骨的贡献更大，因此手术通常会承受大量的术中失血。基于这些临床观察，我们着手研究血管信号在 H2O 中的作用。血管内皮生长因子 A (VEGFA) 先前已被证明是正常骨骼发育和体内平衡过程中关键的促血管生成和促骨生成线索。我们的研究结果，使用经过验证的 HO 小鼠模型，证明 HO 病变具有高度血管性，并且 VEGFA 对异位骨形成至关重要，
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