Cyclin-dependent kinase 2 (CDK2) plays a pivotal part in cell cycle regulation and is involved in a range of biological processes. CDK2 interacts with and phosphorylates proteins in pathways such as DNA damage, intracellular transport, protein degradation, signal transduction, DNA and RNA metabolism and translation. CDK2 and its regulatory subunits are deregulated in many human cancers and there is emerging evidence suggesting CDK2 inhibition elicits antitumor activity in a subset of tumors with defined genetic features. Previous CDK2 inhibitors were nonspecific and limited by off-target effects. The development of new-generation CDK2 inhibitors represents a therapeutic opportunity for CDK2-dependent cancers.

中文翻译：

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在癌症中靶向CDK2：治疗的挑战和机遇。

细胞周期蛋白依赖性激酶2（CDK2）在细胞周期调控中起着关键作用，并参与一系列生物学过程。CDK2在诸如DNA损伤，细胞内转运，蛋白质降解，信号转导，DNA和RNA代谢和翻译等途径中与蛋白质相互作用并使其磷酸化。CDK2及其调节亚基在许多人类癌症中均被解除调节，并且有新出现的证据表明CDK2抑制可在具有明确遗传特征的部分肿瘤中引发抗肿瘤活性。以前的CDK2抑制剂是非特异性的，并受脱靶作用的限制。新一代CDK2抑制剂的开发为依赖CDK2的癌症提供了治疗机会。