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A highly efficient method for the construction of cyclopropane-containing dihydroindole derivatives from indolemethylenecyclopropanes with DIAD and DEAD.
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2019-12-17 , DOI: 10.1039/c9ob02520k Mintao Chen 1 , Wenqing Zang , Yin Wei , Min Shi
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2019-12-17 , DOI: 10.1039/c9ob02520k Mintao Chen 1 , Wenqing Zang , Yin Wei , Min Shi
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A highly efficient method for the construction of cyclopropane-containing dihydroindole derivatives from indolemethylenecyclopropanes with DIAD and DEAD has been disclosed. The transformation could occur under catalyst-free conditions at ambient temperature to afford dihyroindole derivatives in good yields. It has been proved that the strained moiety of methylenecyclopropane in the substrate of indolemethylenecyclopropane is critical and DFT calculations reveal that the reaction proceeds through a two-step pathway.
中文翻译：
一种用DIAD和DEAD从吲哚亚甲基环丙烷构造含环丙烷的二氢吲哚衍生物的高效方法。
已经公开了一种利用DIAD和DEAD由吲哚亚甲基环丙烷构造含环丙烷的二氢吲哚衍生物的高效方法。该转化可以在室温下在无催化剂的条件下发生，以良好的产率提供二氢吲哚衍生物。已经证明吲哚亚甲基环丙烷底物中亚甲基环丙烷的应变部分是关键的，并且DFT计算显示该反应通过两步途径进行。
更新日期：2020-01-02
中文翻译：
一种用DIAD和DEAD从吲哚亚甲基环丙烷构造含环丙烷的二氢吲哚衍生物的高效方法。
已经公开了一种利用DIAD和DEAD由吲哚亚甲基环丙烷构造含环丙烷的二氢吲哚衍生物的高效方法。该转化可以在室温下在无催化剂的条件下发生，以良好的产率提供二氢吲哚衍生物。已经证明吲哚亚甲基环丙烷底物中亚甲基环丙烷的应变部分是关键的，并且DFT计算显示该反应通过两步途径进行。
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