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Antifungal Sesquiterpenoids, Rhodocoranes, from Submerged Cultures of the Wrinkled Peach Mushroom, Rhodotus palmatus.
Journal of Natural Products ( IF 3.3 ) Pub Date : 2019-12-10 , DOI: 10.1021/acs.jnatprod.9b00871 Birthe Sandargo 1, 2 , Maira Michehl 1, 2 , Marc Stadler 1, 2 , Frank Surup 1, 2
Journal of Natural Products ( IF 3.3 ) Pub Date : 2019-12-10 , DOI: 10.1021/acs.jnatprod.9b00871 Birthe Sandargo 1, 2 , Maira Michehl 1, 2 , Marc Stadler 1, 2 , Frank Surup 1, 2
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Seven previously unknown sesquiterpenoids and norsesquiterpenoids, rhodocoranes F-L (1-7), were isolated from the fermentation broth of the basidiomycete Rhodotus palmatus. Their structures were elucidated utilizing 1D and 2D NMR techniques as well as HRESIMS; they are unusual noracorane, spiro[4.4]nonene, and acorane-type sesquiterpenoids. They include the first naturally occurring cyclopentylidenefuranones (3-5) and the new tricyclic scaffold of 7. Metabolites 1-7 exhibited a general mild antimycotic activity, while 1-3 also displayed cytotoxic effects.
中文翻译：
抗真菌倍半萜类化合物 Rhodocoranes，来自皱皮桃蘑菇的淹没培养物，Rhodotus palmatus。
从担子菌Rhodotus palmatus 的发酵液中分离出七种以前未知的倍半萜类化合物和norsesquiterpenoids 类红花烷FL (1-7)。使用一维和二维核磁共振技术以及 HRESIMS 阐明了它们的结构；它们是不寻常的 noracorane、spiro [4.4] 壬烯和 acorane 型倍半萜类化合物。它们包括第一个天然存在的环戊二烯呋喃酮 (3-5) 和 7 的新三环支架。代谢物 1-7 表现出一般温和的抗真菌活性，而 1-3 也表现出细胞毒性作用。
更新日期：2019-12-11
中文翻译：
抗真菌倍半萜类化合物 Rhodocoranes，来自皱皮桃蘑菇的淹没培养物，Rhodotus palmatus。
从担子菌Rhodotus palmatus 的发酵液中分离出七种以前未知的倍半萜类化合物和norsesquiterpenoids 类红花烷FL (1-7)。使用一维和二维核磁共振技术以及 HRESIMS 阐明了它们的结构；它们是不寻常的 noracorane、spiro [4.4] 壬烯和 acorane 型倍半萜类化合物。它们包括第一个天然存在的环戊二烯呋喃酮 (3-5) 和 7 的新三环支架。代谢物 1-7 表现出一般温和的抗真菌活性，而 1-3 也表现出细胞毒性作用。
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