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Teaching an old dog new tricks: metformin induces body-weight loss via GDF15.
Nature Metabolism ( IF 18.9 ) Pub Date : 2019-12-09 , DOI: 10.1038/s42255-019-0153-5
Maximilian Kleinert 1, 2 , Timo D Müller 1, 3, 4
Affiliation  

GDF15 is an anorectic hormone that relays systemic stress to the brain. In the current issue of Nature Metabolism, Day et al. elegantly demonstrate that the frontline anti-diabetes drug, metformin, lowers body weight by increasing circulating levels of GDF15.

中文翻译:

教老狗新的窍门:二甲双胍通过GDF15引起体重减轻。

GDF15是一种厌食激素,可将全身性压力传递至大脑。在“自然新陈代谢”的最新一期中,Day等人。优雅地证明一线抗糖尿病药物二甲双胍可通过增加GDF15的循环水平来降低体重。
更新日期:2019-12-11
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