Teaching an old dog new tricks: metformin induces body-weight loss via GDF15.,Nature Metabolism

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Teaching an old dog new tricks: metformin induces body-weight loss via GDF15.
Nature Metabolism ( IF 18.9 ) Pub Date : 2019-12-09 , DOI: 10.1038/s42255-019-0153-5
Maximilian Kleinert _{1,

2} , Timo D Müller _{1,

3,

4}

Affiliation

GDF15 is an anorectic hormone that relays systemic stress to the brain. In the current issue of Nature Metabolism, Day et al. elegantly demonstrate that the frontline anti-diabetes drug, metformin, lowers body weight by increasing circulating levels of GDF15.

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