Transient receptor potential cation channel subfamily V and breast cancer.,Laboratory Investigation

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Transient receptor potential cation channel subfamily V and breast cancer.
Laboratory Investigation ( IF 5.1 ) Pub Date : 2019-12-10 , DOI: 10.1038/s41374-019-0348-0
Choon Leng So ₁ , Michael J G Milevskiy ₂ , Gregory R Monteith _{1,

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Affiliation

Transient receptor potential cation channel subfamily V (TRPV) channels play important roles in a variety of cellular processes. One example includes the sensory role of TRPV1 that is sensitive to elevated temperatures and acidic environments and is activated by the hot pepper component capsaicin. Another example is the importance of the highly Ca2+ selective channels TRPV5 and TRPV6 in Ca2+ absorption/reabsorption in the intestine and kidney. However, in some cases such as TRPV4 and TRPV6, breast cancer cells appear to overexpress TRPV channels. Moreover, TRPV mediated Ca2+ influx may contribute to enhanced breast cancer cell proliferation and other processes important in tumor progression such as angiogenesis. It appears that the overexpression of some TRPV channels in breast cancer and/or their involvement in breast cancer cell processes, processes important in the tumor microenvironment or pain may make some TRPV channels potential targets for breast cancer therapy. In this review, we provide an overview of TRPV expression in breast cancer subtypes, the roles of TRPV channels in various aspects of breast cancer progression and consider implications for future therapeutic approaches.

中文翻译：

瞬时受体电位阳离子通道亚家族 V 和乳腺癌。

瞬时受体电位阳离子通道亚家族 V (TRPV) 通道在各种细胞过程中起着重要作用。一个例子包括 TRPV1 的感官作用，它对高温和酸性环境敏感，并被辣椒成分辣椒素激活。另一个例子是高 Ca2+ 选择性通道 TRPV5 和 TRPV6 在肠和肾中 Ca2+ 吸收/重吸收中的重要性。然而，在某些情况下，例如 TRPV4 和 TRPV6，乳腺癌细胞似乎过度表达 TRPV 通道。此外，TRPV 介导的 Ca2+ 流入可能有助于增强乳腺癌细胞增殖和其他在肿瘤进展中重要的过程，例如血管生成。似乎某些 TRPV 通道在乳腺癌中的过度表达和/或它们参与乳腺癌细胞过程，在肿瘤微环境或疼痛中重要的过程可能使一些 TRPV 通道成为乳腺癌治疗的潜在目标。在这篇综述中，我们概述了 TRPV 在乳腺癌亚型中的表达、TRPV 通道在乳腺癌进展的各个方面的作用，并考虑了对未来治疗方法的影响。

更新日期：2019-12-11

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