Asymptomatic hyperuricaemia: a silent activator of the innate immune system.,Nature Reviews Rheumatology

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Asymptomatic hyperuricaemia: a silent activator of the innate immune system.
Nature Reviews Rheumatology ( IF 29.4 ) Pub Date : 2019-12-10 , DOI: 10.1038/s41584-019-0334-3
Leo A B Joosten _{1,

2} , Tania O Crişan ₁ , Petter Bjornstad ₃ , Richard J Johnson ₃

Affiliation

Asymptomatic hyperuricaemia affects ~20% of the general population in the USA, with variable rates in other countries. Historically, asymptomatic hyperuricaemia was considered a benign laboratory finding with little clinical importance in the absence of gout or kidney stones. Yet, increasing evidence suggests that asymptomatic hyperuricaemia can predict the development of hypertension, obesity, diabetes mellitus and chronic kidney disease and might contribute to disease by stimulating inflammation. Although urate has been classically viewed as an antioxidant with beneficial effects, new data suggest that both crystalline and soluble urate activate various pro-inflammatory pathways. This Review summarizes what is known about the role of urate in the inflammatory response. Further research is needed to define the role of asymptomatic hyperuricaemia in these pro-inflammatory pathways.

中文翻译：

无症状高尿酸血症：先天免疫系统的沉默激活剂。

无症状高尿酸血症影响美国约 20% 的总人口，而其他国家的发病率各不相同。历史上，无症状高尿酸血症被认为是良性实验室发现，在没有痛风或肾结石的情况下几乎没有临床意义。然而，越来越多的证据表明，无症状高尿酸血症可以预测高血压、肥胖、糖尿病和慢性肾病的发展，并可能通过刺激炎症而导致疾病。尽管尿酸盐传统上被认为是一种具有有益作用的抗氧化剂，但新数据表明，结晶尿酸盐和可溶性尿酸盐都会激活各种促炎途径。本综述总结了尿酸盐在炎症反应中的作用的已知信息。需要进一步研究来明确无症状高尿酸血症在这些促炎症途径中的作用。

更新日期：2019-12-11

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