INTRODUCTION Streptococcus agalactiae (group B streptococci; GBS) is an uncommon cause of bacterial meningitis in adults. METHODS We reviewed literature published between 1975 and 2018. Studies were included if they reported age, sex and outcome of patients above 16 years of age with cerebrospinal fluid culture (CSF) positive for GBS. RESULTS Sixty-seven articles describing 141 patients were included. Median age was 56 years (IQR 41-66); 52% were male. Fifty-three patients (38%) were immunocompromised and CSF leakage was reported in 9 (10%) of 88 immunocompetent patients. Sixty-two patients (44%) had extra-meningeal foci of infection, most commonly endocarditis, which occurred in 14 patients (12%). Twenty-eight patients (23%) were described as previously healthy. Forty-four (31%) of the 141 patients died, after a median duration of 5 days after admission. Death was associated with advanced age and an immunocompromised state. CONCLUSION GBS meningitis in adults mainly occurs in those with underlying conditions such as immunocompromised state, CSF leakage, and endocarditis. These conditions should be actively sought for in adults with GBS meningitis.

中文翻译：

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成人社区获得性B组链球菌性脑膜炎。

简介无乳链球菌（B组链球菌； GBS）是成年人细菌性脑膜炎的罕见病因。方法我们回顾了1975年至2018年之间发表的文献。如果研究报告了年龄，性别和16岁以上脑脊液培养（CSF）GBS阳性患者的结局，则纳入研究。结果纳入67篇文章，描述141例患者。中位年龄为56岁（IQR 41-66）；52％是男性。免疫功能低下的患者有53例（38％），在88例具有免疫能力的患者中有9例（10％）报告脑脊液渗漏。62例患者（44％）感染了脑膜外病灶，最常见的是心内膜炎，发生在14例患者中（12％）。28名患者（23％）被描述为先前健康。141名患者中有44名（31％）死亡，入院后中位数为5天。死亡与高龄和免疫功能低下有关。结论成人GBS脑膜炎主要发生在免疫力低下，脑脊液漏出和心内膜炎等潜在疾病中。对于患有GBS脑膜炎的成人，应积极寻求这些条件。