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One-Pot Synthesis of Unsymmetrical Bis-Heterocycles: Benzimidazole-, Benzoxazole-, and Benzothiazole-Linked Thiazolidines.
ACS Combinatorial Science Pub Date : 2019-12-09 , DOI: 10.1021/acscombsci.9b00161
Hsueh-Yuan Lu,Indrajeet J Barve,Manikandan Selvaraju,Chung-Ming Sun

A one-pot, three-component synthesis of benzimidazole-linked thiazolidines from 2-cyanomethyl benzimidazole, iso-, isothio-, or isoselenocyanates and 1,2-dichloroethane is reported. Isolation of the key intermediate formed during the course of the reaction validates its mechanistic pathway. Under the same reaction conditions, benzimidazole-linked/fused thiazinanes were obtained when 1,3-dichloropropane or diiodomethane was used.

中文翻译:

一锅合成不对称的双杂环:苯并咪唑,苯并恶唑和苯并噻唑连接的噻唑烷。

据报道,由2-氰基甲基苯并咪唑,异-,异硫代或异异戊烯酸酯和1,2-二氯乙烷一锅三组分合成苯并咪唑连接的噻唑烷。反应过程中形成的关键中间体的分离验证了其机理途径。在相同的反应条件下,当使用1,3-二氯丙烷或二碘甲烷时,可获得苯并咪唑连接/稠合的噻嗪酮。
更新日期:2019-12-11
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