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Nigrosome 1 imaging in REM sleep behavior disorder and its association with dopaminergic decline.
Annals of Clinical and Translational Neurology ( IF 4.4 ) Pub Date : 2019-12-09 , DOI: 10.1002/acn3.50962
Thomas R Barber 1, 2, 3 , Ludovica Griffanti 1, 2, 4 , Kevin M Bradley 5 , Daniel R McGowan 6 , Christine Lo 1, 2 , Clare E Mackay 1, 3 , Michele T Hu 1, 2 , Johannes C Klein 1, 2, 3, 4
Affiliation  

Rapid eye movement sleep behavior disorder (RBD) patients have a high risk of developing a Parkinsonian disorder, offering an opportunity for neuroprotective intervention. Predicting near‐term conversion, however, remains a challenge. Dopamine transporter imaging, while informative, is expensive and not widely available. Here, we investigate the utility of susceptibility‐weighted MRI (SWI) to detect abnormalities of the substantia nigra in RBD, and explore their association with striatal dopaminergic deficits.

中文翻译:

REM 睡眠行为障碍中的 Nigrosome 1 成像及其与多巴胺能下降的关联。

快速眼动睡眠行为障碍 (RBD) 患者患帕金森病的风险很高,为神经保护干预提供了机会。然而,预测近期转换仍然是一个挑战。多巴胺转运蛋白成像虽然信息丰富,但价格昂贵且无法广泛使用。在这里,我们研究了磁敏感加权 MRI (SWI) 在检测 RBD 中黑质异常方面的效用,并探讨了它们与纹状体多巴胺能缺陷的关系。
更新日期:2019-12-09
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