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Interleukin 31 in insect bite hypersensitivity – Alleviating clinical symptoms by active vaccination against itch
Allergy ( IF 12.6 ) Pub Date : 2020-02-06 , DOI: 10.1111/all.14145
Florian Olomski 1, 2 , Victoria Fettelschoss 1, 2, 3 , Sigridur Jonsdottir 4 , Katharina Birkmann 3 , Franziska Thoms 1, 2 , Eliane Marti 4 , Martin F Bachmann 5, 6 , Thomas M Kündig 2, 7 , Antonia Fettelschoss-Gabriel 1, 2, 3
Affiliation  

Insect bite hypersensitivity (IBH) is the most common seasonal pruritic allergic dermatitis of horses occurring upon insect bites. In recent years, a major role for IL‐31 in allergic pruritus of humans, monkeys, dogs, and mice was acknowledged. Here, we investigate the role of IL‐31 in IBH of horses and developed a therapeutic vaccine against equine IL‐31 (eIL‐31).

中文翻译:

昆虫叮咬过敏症中的白细胞介素 31 – 通过主动接种抗痒疫苗缓解临床症状

昆虫叮咬过敏症 (IBH) 是马最常见的季节性瘙痒性过敏性皮炎,由昆虫叮咬引起。近年来,IL-31 在人、猴、狗和小鼠的过敏性瘙痒中的主要作用得到承认。在这里,我们研究了 IL-31 在马的 IBH 中的作用,并开发了一种针对马 IL-31 (eIL-31) 的治疗性疫苗。
更新日期:2020-02-06
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