Designing and engineering materials into particular shapes and/or structural arrangements paves the way to advanced materials properties. Top-down micro/nano fabrication can achieve patterns with sub-10 nm precision; however, challenges and limitations in material versatility, dynamic arrangement, biocompatibility, and high cost still exist. Bottom-up methods, however, allow elements to grow/assemble into well-defined structures. Along with the prosperity in the field of structural DNA nanotechnology, DNA as a mature programmable polymer has been fascinating in organizing materials into complex nanostructures. In this review article, we briefly introduce key achievements of DNA nanotechnology, summarize the current progress of DNA nanostructure-based material programming and molding, and discuss the limitations and challenges of this challenging field.

将材料设计和工程化为特定的形状和/或结构安排为提高材料性能铺平了道路。自上而下的微/纳米制造可以实现低于10 nm的精度的图案；然而，在材料的多功能性，动态排列，生物相容性和高成本方面仍然存在挑战和局限性。但是，自下而上的方法允许元素增长/组装为定义明确的结构。随着结构DNA纳米技术领域的繁荣，DNA作为一种成熟的可编程聚合物，一直在将材料组织成复杂的纳米结构而着迷。在这篇评论文章中，我们简要介绍了DNA纳米技术的主要成就，总结了基于DNA纳米结构的材料编程和成型的最新进展，