Adenosine is a key metabolic and immune-checkpoint regulator implicated in the tumor escape from the host immune system. Major gaps in knowledge that impede the development of effective adenosine-based therapeutics include: (1) lack of consideration of redundant pathways controlling ATP and adenosine levels; (2) lack of distinction between receptor-dependent and -independent effects of adenosine, and (3) focus on extracellular adenosine without consideration of intracellular metabolism and compartmentalization. In light of current clinical trials, we provide an overview of adenosine metabolism and point out the need for a more careful evaluation of the entire purinome in emerging cancer therapies.

中文翻译：

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腺苷代谢：癌症治疗的新兴概念。

腺苷是关键的代谢和免疫检查点调节剂，与肿瘤从宿主免疫系统逃逸有关。阻碍有效的基于腺苷的疗法的发展的主要知识差距包括：（1）缺乏考虑控制ATP和腺苷水平的冗余途径；（2）腺苷的受体依赖性和非依赖性效应之间缺乏区别，并且（3）集中在细胞外腺苷而不考虑细胞内代谢和区室化。根据当前的临床试验，我们提供了腺苷代谢的概述，并指出了在新兴的癌症治疗中需要对整个嘌呤组进行更仔细评估的必要性。