The nucleus houses and protects genomic DNA, which is surrounded by the nuclear envelope. Owing to its size and stiffness, the nucleus is often a barrier to migration through confined spaces. Neutrophils are terminally differentiated, short-lived cells that migrate through tissues in response to injury and infections. The neutrophil nucleus is soft, multilobular, and exhibits altered levels of key nuclear envelope proteins. These alterations result in a multifunctional organelle that serves as a signaling hub during migration and NETosis, a process by which neutrophils release decondensed chromatin decorated with granular enzymes that entrap pathogens. In this review, we present emerging evidence suggesting that a unique, ambiguous cell-cycle state is critical for NETosis and migration. Finally, we discuss how the mechanisms underlying migration and NETosis are evolutionarily conserved.

中文翻译：

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在中性粒细胞信号中继和NETosis期间，核的新兴作用。

核容纳并保护被核被膜包围的基因组DNA。由于其大小和刚度，原子核通常是在狭窄空间中迁移的障碍。中性粒细胞是终末分化的，短寿命的细胞，可响应损伤和感染而在组织中迁移。中性粒细胞核柔软，多叶，并显示出关键核被膜蛋白水平的改变。这些改变导致多功能细胞器在迁移和NETosis期间充当信号枢纽，中性粒细胞通过该过程释放脱凝的染色质，该染色质装饰有捕获病原体的颗粒酶。在这篇综述中，我们提出了新的证据，表明独特的，模棱两可的细胞周期状态对于NETosis和迁移至关重要。最后，