Half-sandwich organometallic complexes featuring Ru(II), Os(II) and Rh(III) metal centers and naturally occurring bidentate 2-hydroxy-[1,4]-naphthoquinone ligands (lawsone and phthiocol) have been synthesized and characterized in both solid state and solution phase by analytical, spectroscopic, electrochemical and single crystal X-ray diffraction techniques. Comparative studies revealed the influence of the respective metal center (Ru, Os, Rh), leaving group (Cl, Br, I) and arene (p-cymene, toluene, pentamethylcyclopentadienyl), as well as the naphthoquinone ligand on the structural properties and solution speciation. Additionally, cytotoxicity was tested in SW480, CH1/PA-1 and A549 human cancer cell lines showing a broad range of IC₅₀ values.

合成并表征了具有Ru（II），Os（II）和Rh（III）金属中心和天然存在的双齿2-羟基-[[1,4]-萘醌配体（拉索酮和苯硫酚）的半三明治有机金属配合物通过分析，光谱，电化学和单晶X射线衍射技术获得固态和溶液相。比较研究表明，各自的金属中心（Ru，Os，Rh），离去基团（Cl，Br，I）和芳烃（对-Cymene，甲苯，五甲基环戊二烯基）以及萘醌配体对结构性能和结构的影响。解决方案形态。此外，在SW480，CH1 / PA-1和A549人癌细胞系中测试了细胞毒性，显示出广泛的IC ₅₀值。