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Iron oxide nanoparticle core-shell magnetic microspheres: Applications toward targeted drug delivery
Nanomedicine: Nanotechnology, Biology and Medicine ( IF 5.570 ) Pub Date : 2019-12-10 , DOI: 10.1016/j.nano.2019.102134
Srinivasan Ayyanaar, Mookkandi Palsamy Kesavan, Chandrasekar Balachandran, Swetha Rasala, Perumal Rameshkumar, Shin Aoki, Jegathalaprathaban Rajesh, Thomas J. Webster, Gurusamy Rajagopal

This study describes a sensitive reactive oxygen species (ROS)-responsive lecithin (LEC) incorporated iron oxide nanoparticle (Fe3O4 NP) system with potent anti-inflammatory properties and even more so when the antioxidant drug curcumin (CUR) is encapsulated in the PLGA hybrid magnetic microsphere system (Fe3O4@LEC-CUR-PLGA-MMS). The delivery system is responsive to ROS including an H2O2 environment to release the payload (CUR) drug. Greater cytotoxicity properties were observed in the presence of Fe3O4@LEC-CUR-PLGA-MMS against A549 and HeLa S3 cells with IC50 values after 24 h of 10 and 12 μg/mL and 10 and 20 μg/mL, respectively. The present Fe3O4@LEC-CUR-PLGA-MMS system demonstrated much better in vitro cytotoxicity, cellular morphological changes and moreover an ability to limit colony formation for A549 and HeLa S3 cancer cell lines than non-cancerous cells, and thus, should be further studied for a wide range of medical applications.
更新日期:2019-12-11

 

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