This study describes a sensitive reactive oxygen species (ROS)-responsive lecithin (LEC) incorporated iron oxide nanoparticle (Fe3O4 NP) system with potent anti-inflammatory properties and even more so when the antioxidant drug curcumin (CUR) is encapsulated in the PLGA hybrid magnetic microsphere system (Fe3O4@LEC-CUR-PLGA-MMS). The delivery system is responsive to ROS including an H2O2 environment to release the payload (CUR) drug. Greater cytotoxicity properties were observed in the presence of Fe3O4@LEC-CUR-PLGA-MMS against A549 and HeLa S3 cells with IC50 values after 24 h of 10 and 12 μg/mL and 10 and 20 μg/mL, respectively. The present Fe3O4@LEC-CUR-PLGA-MMS system demonstrated much better in vitro cytotoxicity, cellular morphological changes and moreover an ability to limit colony formation for A549 and HeLa S3 cancer cell lines than non-cancerous cells, and thus, should be further studied for a wide range of medical applications.

中文翻译：

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氧化铁纳米颗粒核-壳磁性微球：靶向药物输送的应用。

这项研究描述了一种敏感的活性氧（ROS）-反应性卵磷脂（LEC）掺入的氧化铁纳米颗粒（Fe3O4 NP）系统，具有强大的抗炎特性，当将抗氧化剂姜黄素（CUR）封装在PLGA杂种中时更是如此磁微球系统（Fe3O4 @ LEC-CUR-PLGA-MMS）。输送系统对包括H2O2环境的ROS做出响应，以释放有效载荷（CUR）药物。在Fe3O4 @ LEC-CUR-PLGA-MMS的存在下，观察到对A549和HeLa S3细胞的更大的细胞毒性，其在24 h后的IC50值分别为10μg/ mL和12μg/ mL，以及10μg/ mL和20μg/ mL。目前的Fe3O4 @ LEC-CUR-PLGA-MMS系统显示出更好的体外细胞毒性，