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Relevance of Nrf2 and heme oxygenase-1 in articular diseases.
Free Radical Biology and Medicine ( IF 7.1 ) Pub Date : 2019-12-09 , DOI: 10.1016/j.freeradbiomed.2019.12.007
Maria José Alcaraz 1 , María Luisa Ferrándiz 1
Affiliation  

Joint conditions pose an important public health problem as they are a leading cause of pain, functional limitation and physical disability. Oxidative stress is related to the pathogenesis of many chronic diseases affecting the joints such as rheumatoid arthritis and osteoarthritis. Cells have developed adaptive protection mechanisms to maintain homeostasis such as nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) which regulates the transcription of many genes involved in redox balance, detoxification, metabolism and inflammation. Activation of Nrf2 results in the synthesis of heme oxygenase-1 (HO-1) leading to the formation of a number of bioactive metabolites, mainly CO, biliverdin and bilirubin. Ample evidence supports the notion that Nrf2 and HO-1 can confer protection against oxidative stress and inflammatory and immune responses in joint tissues. As a consequence, this pathway may control the activation and metabolism of articular cells to play a regulatory role in joint destruction thus offering new opportunities for better treatments. Further studies are necessary to identify improved strategies to regulate Nrf2 and HO-1 activation in order to enable the development of drugs with therapeutic applications in joint diseases.

中文翻译:

Nrf2和血红素加氧酶1在关节疾病中的相关性。

关节疾病是一个重要的公共卫生问题,因为它们是导致疼痛、功能受限和身体残疾的主要原因。氧化应激与许多影响关节的慢性疾病的发病机制有关,例如类风湿性关节炎和骨关节炎。细胞已经发展出适应性保护机制来维持体内平衡,例如核因子红细胞 2 (NF-E2) 相关因子 2 (Nrf2),它调节参与氧化还原平衡、解毒、代谢和炎症的许多基因的转录。Nrf2 的激活导致血红素加氧酶-1 (HO-1) 的合成,从而导致形成许多生物活性代谢物,主要是 CO、胆绿素和胆红素。大量证据支持 Nrf2 和 HO-1 可以保护关节组织免受氧化应激以及炎症和免疫反应的观点。因此,该途径可能控制关节细胞的活化和代谢,从而在关节破坏中发挥调节作用,从而为更好的治疗提供新的机会。需要进一步的研究来确定调节 Nrf2 和 HO-1 活化的改进策略,以便能够开发在关节疾病中具有治疗应用的药物。
更新日期:2019-12-09
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