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Statistical reporting of metabolomics data: experience from a high-throughput NMR platform and epidemiological applications.
Metabolomics ( IF 3.5 ) Pub Date : 2019-12-10 , DOI: 10.1007/s11306-019-1626-y
Stefan Mutter 1, 2, 3, 4 , Carrie Worden 5 , Kara Paxton 5 , Ville-Petteri Mäkinen 1, 6
Affiliation  

INTRODUCTION Meta-analysis is the cornerstone of robust biomedical evidence. OBJECTIVES We investigated whether statistical reporting practices facilitate metabolomics meta-analyses. METHODS A literature review of 44 studies that used a comparable platform. RESULTS Non-numeric formats were used in 31 studies. In half of the studies, less than a third of all measures were reported. Unadjusted P-values were missing from 12 studies and exact P-values from 9 studies. CONCLUSION Reporting practices can be improved. We recommend (i) publishing all results as numbers, (ii) reporting effect sizes of all measured metabolites and (iii) always reporting unadjusted exact P-values.

中文翻译:

代谢组学数据的统计报告:高通量NMR平台和流行病学应用的经验。

引言荟萃分析是强有力的生物医学证据的基础。目的我们调查了统计报告实践是否有助于代谢组学的荟萃分析。方法对44项使用可比平台的研究进行文献综述。结果31项研究使用了非数字格式。在一半的研究中,报告不到所有措施的三分之一。12项研究缺少未调整的P值,而9项研究缺少准确的P值。结论可以改进报告做法。我们建议(i)将所有结果发布为数字,(ii)报告所有测量代谢物的作用大小,以及(iii)始终报告未调整的精确P值。
更新日期:2019-12-10
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