Ethenesulfonyl Fluoride (ESF) and Its Derivatives in SuFEx Click Chemistry and More,Synthesis

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Ethenesulfonyl Fluoride (ESF) and Its Derivatives in SuFEx Click Chemistry and More
Synthesis ( IF 2.2 ) Pub Date : 2019-12-09 , DOI: 10.1055/s-0039-1690038
Yan-Ping Meng ₁ , Shi-Meng Wang _{1,

2} , Wan-Yin Fang _{1,

2} , Zhi-Zhong Xie ₁ , Jing Leng _{1,

2} , Hamed Alsulami ₃ , Hua-Li Qin _{1,

2}

Affiliation

The sulfur(VI) fluoride exchange reaction (SuFEx), developed by Sharpless and co-workers in 2014, is a new category of click reaction that creates molecular connections with absolute reliability and unprecedented efficiency through a sulfur(VI) hub. Ethenesulfonyl fluoride (ESF), as one of the most important sulfur(VI) hubs, exhibits extraordinary reactivity in SuFEx click chemistry and organic synthesis. This review summarizes the chemical properties and applications of ESF in click chemistry, organic chemistry, materials science, medicinal chemistry and in many other fields related to organic synthesis.

中文翻译：

SuFEx点击化学中的乙磺酰基氟化物（ESF）及其衍生物

Sharpless及其同事于2014年开发的硫（VI）氟化物交换反应（SuFEx）是一种新型点击反应，可通过硫（VI）中心建立具有绝对可靠性和空前效率的分子连接。乙磺酰氟（ESF）作为最重要的硫（VI）中心之一，在SuFEx点击化学和有机合成中表现出非凡的反应活性。这篇综述总结了ESF的化学性质及其在点击化学，有机化学，材料科学，药物化学以及许多其他与有机合成相关的领域中的应用。

更新日期：2019-12-11

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