Transition-Metal-Free Aerobic Oxidative Cross-Coupling of Indoles with Arylidenemalononitriles,Synlett

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Transition-Metal-Free Aerobic Oxidative Cross-Coupling of Indoles with Arylidenemalononitriles
Synlett ( IF 1.7 ) Pub Date : 2019-12-10 , DOI: 10.1055/s-0039-1691532
Aizhen Yang , Zheng Li ₁

Affiliation

An efficient method for the direct construction of C(sp2)–C(sp2) bonds by aerobic oxidative cross-coupling of indoles with arylidenemalononitriles is described. Various [aryl(1H-indol-3-yl)methylene]malononitriles were efficiently synthesized by using air as an oxidant under mild conditions. The salient features for this protocol are no transition-metal catalysts, no organometallic reagents, high atom economy, high yield, mild conditions, and simple workup procedures.

中文翻译：

吲哚与亚芳基丙二腈的无过渡金属有氧氧化交叉偶联

描述了通过吲哚与亚芳基丙二腈的有氧氧化交叉偶联直接构建 C(sp2)–C(sp2) 键的有效方法。以空气为氧化剂，在温和条件下高效合成了各种[芳基(1H-吲哚-3-基)亚甲基]丙二腈。该协议的显着特点是没有过渡金属催化剂、没有有机金属试剂、高原子经济性、高产率、温和的条件和简单的后处理程序。

更新日期：2019-12-10

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