Two new aromatic polyketides from a sponge-derived Fusarium.,Beilstein Journal of Organic Chemistry

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Two new aromatic polyketides from a sponge-derived Fusarium.
Beilstein Journal of Organic Chemistry ( IF 2.2 ) Pub Date : 2019-12-09 , DOI: 10.3762/bjoc.15.289
Mada Triandala Sibero _{1,

2} , Tao Zhou ₃ , Keisuke Fukaya ₃ , Daisuke Urabe ₃ , Ocky K Karna Radjasa ₁ , Agus Sabdono ₁ , Agus Trianto ₁ , Yasuhiro Igarashi ₃

Affiliation

In our natural product screening program from marine fungi, two new aromatic polyketides karimunones A (1) and B (2) and five known compounds (3-7) were isolated from sponge-associated Fusarium sp. KJMT.FP.4.3 which was collected from an Indonesian sponge Xestospongia sp. The structures of these compounds were determined by the analysis of NMR and MS spectroscopic data. The NMR assignment of 1 was assisted by DFT-based theoretical chemical shift calculation. Compound 2 showed antibacterial activity against multidrug resistant Salmonella enterica ser. Typhi with a MIC of 125 µg/mL while 1 was not active.

中文翻译：

源自海绵的镰刀菌中的两种新的芳香族聚酮化合物。

在我们从海洋真菌中筛选天然产物的程序中，从海绵相关的镰刀菌属中分离了两个新的芳香族聚酮化合物香豆酮A（1）和B（2）以及五个已知的化合物（3-7）。KJMT.FP.4.3是从印度尼西亚海绵Xestospongia sp。这些化合物的结构是通过NMR和MS光谱数据分析确定的。NMR分配1通过基于DFT的理论化学位移计算得到辅助。化合物2显示出对多重耐药性肠炎沙门氏菌的抗菌活性。伤寒（MIC）为125 µg / mL的伤寒菌，而1则没有活性。

更新日期：2019-12-09

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