Abstract A central challenge in the field of electrophysiology is to achieve intracellular recording of the complex networks of electrogenic cells in tissues. The historical gold-standard of intracellular recording - patch-clamp electrodes - do have limitations in terms of their invasiveness and difficulty to use in large-scale parallel recording. Recent advances in nanowire-based bioelectronics have demonstrated minimally-invasive intracellular interfaces and highly-scalable parallel recording at the network level. Combined with in vivo recording platforms, these advances can enable investigations of dynamics in the brain and drive the development of new brain-machine interfaces with unprecedented resolution and precision.

中文翻译：

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纳米线探针可以驱动高分辨率脑机接口

摘要 电生理学领域的一个核心挑战是实现组织中生电细胞复杂网络的细胞内记录。细胞内记录的历史黄金标准 - 膜片钳电极 - 在其侵入性和难以在大规模并行记录中使用方面确实存在局限性。基于纳米线的生物电子学的最新进展已经证明了微创的细胞内接口和网络级别的高度可扩展的并行记录。结合体内记录平台，这些进步可以研究大脑中的动力学，并以前所未有的分辨率和精度推动新脑机接口的开发。