A reversible, switchable pH-driven quaternary ammonium pillar[5]arene nanogate for mesoporous silica nanoparticles.,Journal of Materials Chemistry B

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A reversible, switchable pH-driven quaternary ammonium pillar[5]arene nanogate for mesoporous silica nanoparticles.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2019-12-23 , DOI: 10.1039/c9tb00946a
Evelyn C S Santos ₁ , Thiago C Dos Santos ₁ , Tamires S Fernandes ₁ , Fernanda L Jorge ₂ , Vanessa Nascimento ₃ , Vinicius G C Madriaga ₁ , Pâmella S Cordeiro ₃ , Noemi R Checca ₄ , Nathalia Meireles Da Costa ₂ , Luís Felipe Ribeiro Pinto ₂ , Célia M Ronconi ₁

Affiliation

Here we describe the assembly and pH-driven operation of two nanocarriers based on non-functionalized (MCM-41) and carboxylate-functionalized (MCM-41-COOH) containers loaded with the anticancer drug doxorubicin (DOX) and capped by quaternary ammonium pillar[5]arene (P[5]A) nanogates. MCM-41 and MCM-41-COOH containers were synthesized and transmission and scanning electron microscopies showed nanoparticles with spherical morphology and dimensions of 85 ± 13 nm. The nanochannels of MCM-41 loaded with DOX were gated through the electrostatic interactions between P[5]A and the silanolate groups formed at the silica-water interface, yielding the MCM-41-DOX-P[5]A nanocarrier. The second nanocarrier was gated through the electrostatic interactions between the carboxylate groups mounted on the surface of MCM-41 and P[5]A, resulting in the MCM-41-COO-DOX-P[5]A nanocarrier. The DOX release profiles from both nanocarriers were investigated by UV-vis spectroscopy at different pH values (2.0, 5.5 and 7.4) and also in the presence of ions, such as citrate3- (19 mmol L-1) and Zn2+ (1.2 and 50 mmol L-1) at 37 °C. MCM-41-COO-DOX-P[5]A can be turned on and off eight times through the formation and breaking of electrostatic interactions. In vitro studies show that MCM-41-COO-DOX-P[5]A can penetrate and release DOX in the nucleus of human breast adenocarcinoma MCF-7 cancer cells leading to a pronounced cytotoxic effect. Therefore, the fabricated nanocarrier based on a water-soluble cationic pillar[5]arene nanogate, which is reversibly opened and closed by electrostatic interactions, can be considered as a promising drug transport and delivery technique for future cancer therapy.

中文翻译：

一种可逆的，可转换的pH驱动的季铵柱[5]芳烃纳米门，用于介孔二氧化硅纳米粒子。

在这里，我们描述了两种基于非功能化（MCM-41）和羧酸盐官能化（MCM-41-COOH）容器的纳米载体的组装和pH驱动操作，该容器装有抗癌药阿霉素（DOX）并被季铵柱覆盖[5]芳烃（P [5] A）纳米门。合成了MCM-41和MCM-41-COOH容器，透射电子显微镜和扫描电子显微镜显示纳米颗粒具有球形形态，尺寸为85±13 nm。负载DOX的MCM-41纳米通道通过P [5] A与在二氧化硅-水界面形成的硅烷醇基之间的静电相互作用进行门控，从而产生MCM-41-DOX-P [5] A纳米载体。通过安装在MCM-41和P [5] A表面上的羧酸酯基之间的静电相互作用，门控了第二个纳米载体，产生MCM-41-COO-DOX-P [5] A纳米载体。通过在不同pH值（2.0、5.5和7.4）以及存在离子（例如柠檬酸根3-（19 mmol L-1）和Zn2 +（1.2和50）的情况下的紫外-可见光谱法研究了两种纳米载体的DOX释放曲线。毫摩尔L-1）在37°C下。通过形成和破坏静电相互作用，MCM-41-COO-DOX-P [5] A可以打开和关闭八次。体外研究表明，MCM-41-COO-DOX-P [5] A可以穿透并释放人乳腺腺癌MCF-7癌细胞核中的DOX，从而产生明显的细胞毒性作用。因此，制备了基于水溶性阳离子柱[5]芳烃纳米门的纳米载体，该载体通过静电相互作用可逆地打开和关闭，

更新日期：2019-12-23

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