Plasma metabolite biomarkers of boiled and filtered coffee intake and their association with type 2 diabetes risk.,Journal of Internal Medicine

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Plasma metabolite biomarkers of boiled and filtered coffee intake and their association with type 2 diabetes risk.
Journal of Internal Medicine ( IF 9.0 ) Pub Date : 2019-12-09 , DOI: 10.1111/joim.13009
L Shi _{1,

2} , C Brunius ₂ , I Johansson _{3,

4} , I A Bergdahl _{4,

5} , O Rolandsson ₄ , B van Guelpen _{6,

7} , A Winkvist _{8,

9} , K Hanhineva _{10,

11} , R Landberg _{2,

4}

Affiliation

From the, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an, China.
Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden.
Department of Odontology, Umeå University, Umeå, Sweden.
Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Department of Biobank Research, Umeå University, Umeå, Sweden.
Department of Radiation Sciences, Umeå University, Umeå, Sweden.
Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden.
Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Gothenburg, Sweden.
Department of Public Health and Clinical Medicine, Sustainable Health, Umeå University, Umeå, Sweden.
LC-MS Metabolomics Center, Kuopio, Finland.
Department of Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.

BACKGROUND Habitual coffee intake has been associated with a lower risk of developing type 2 diabetes (T2D), but few studies used biomarkers to reflect intake and investigated different coffee brews, that is boiled and filtered, separately. OBJECTIVES To identify plasma metabolites associated with boiled or filtered coffee intake and to examine their association with T2D risk in Swedish adults. METHODS In a case-control study nested within the Västerbotten Intervention Programme, baseline plasma samples from 421 case-control pairs and samples from a subset of 149 pairs at a 10-year follow-up were analysed using untargeted LC-MS metabolomics. We identified metabolites associated with food frequency questionnaires (FFQ)-estimated coffee intake and assessed odds ratios of T2D. RESULTS In total, 24 and 32 metabolites were associated with boiled or filtered coffee intake. We determined robust metabolite panels for highly specific prediction of boiled or filtered coffee. We observed an inverse association between the metabolite panel of filtered coffee and T2D risk. No association with T2D was observed for the panel of boiled coffee intake. Similar results were observed for FFQ-estimated coffee intake. CONCLUSIONS We identified plasma metabolites specifically associated with boiled or filtered coffee intake, which might be used as selective biomarkers. Our study supports a protective role of habitual intake of filtered coffee on T2D development. The lack of association for boiled coffee intake might be due to the lack of a protective effect of boiled coffee or due to the limited number of boiled coffee consumers in this population, but it warrants further investigation.

中文翻译：

煮咖啡和过滤咖啡的血浆代谢物生物标志物及其与2型糖尿病风险的关系。

背景技术习惯性的咖啡摄入与罹患2型糖尿病（T2D）的风险较低相关，但是很少有研究使用生物标志物来反映摄入量，并研究了分别煮沸和过滤的不同咖啡冲泡剂。目的确定与煮咖啡或过滤咖啡摄入量相关的血浆代谢物，并检查其与瑞典成年人中T2D风险的相关性。方法在嵌套在Västerbotten干预计划中的病例对照研究中，使用非靶向LC-MS代谢组学对来自421个病例对照对的基线血浆样本和来自149对对照子集的样本在10年的随访中进行了分析。我们确定了与食物频率调查表（FFQ）估计的咖啡摄入量相关的代谢物，并评估了T2D的优势比。结果总计 24和32种代谢物与煮沸或过滤的咖啡摄入量有关。我们确定了鲁棒的代谢物面板，可高度准确地预测煮沸或过滤后的咖啡。我们观察到过滤咖啡的代谢产物与T2D风险之间呈负相关。煮沸的咖啡摄入量与T2D无关。FFQ估计的咖啡摄入量观察到相似的结果。结论我们确定了与煮沸或过滤的咖啡摄入量特别相关的血浆代谢物，可将其用作选择性生物标志物。我们的研究支持习惯性摄入过滤咖啡对T2D发育的保护作用。煮咖啡的摄入量缺乏关联性可能是由于煮咖啡的保护作用不足或该人群中煮咖啡的消费者数量有限，

更新日期：2019-12-09

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