Multifunctional temperature‐responsive polymers as advanced biomaterials and beyond,Journal of Applied Polymer Science

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Multifunctional temperature‐responsive polymers as advanced biomaterials and beyond
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2019-12-09 , DOI: 10.1002/app.48770
E Molly Frazar _{1,

2} , Rishabh A Shah _{1,

2} , Thomas D Dziubla _{1,

2} , J Zach Hilt _{1,

2}

Affiliation

The versatility and applicability of thermoresponsive polymeric systems have led to great interest and a multitude of publications. Of particular significance, multifunctional poly(N‐isopropylacrylamide) (PNIPAAm) systems based on PNIPAAm copolymerized with various functional comonomers or based on PNIPAAm combined with nanomaterials exhibiting unique properties. These multifunctional PNIPAAm systems have revolutionized several biomedical fields such as controlled drug delivery, tissue engineering, self‐healing materials, and beyond (e.g., environmental treatment applications). Here, we review these multifunctional PNIPAAm‐based systems with various cofunctionalities, as well as highlight their unique applications. For instance, addition of hydrophilic or hydrophobic comonomers can allow for polymer lower critical solution temperature modification, which is especially helpful for physiological applications. Natural comonomers with desirable functionalities have also drawn significant attention as pressure surmounts to develop greener, more sustainable materials. Typically, these systems also tend to be more biocompatible and biodegradable and can be advantageous for use in biopharmaceutical and environmental applications. PNIPAAm‐based polymeric nanocomposites are reviewed as well, where incorporation of inorganic or carbon nanomaterials creates synergistic systems that tend to be more robust and widely applicable than the individual components. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48770.

中文翻译：

多功能温度响应聚合物作为先进生物材料及其他

热响应聚合物系统的多功能性和适用性引起了人们的极大兴趣和大量出版物。特别重要的是，基于PNIPAAm与各种功能共聚单体共聚或基于PNIPAAm与纳米材料结合的多功能聚（ N-异丙基丙烯酰胺）（PNIPAAm）体系表现出独特的性能。这些多功能 PNIPAAm 系统彻底改变了多个生物医学领域，例如受控药物输送、组织工程、自愈材料等（例如环境处理应用）。在这里，我们回顾了这些具有各种协同功能的基于 PNIPAAm 的多功能系统，并重点介绍了它们的独特应用。例如，添加亲水性或疏水性共聚单体可以允许聚合物降低临界溶液温度，这对于生理应用特别有帮助。随着开发更环保、更可持续的材料的压力越来越大，具有所需功能的天然共聚单体也引起了人们的广泛关注。通常，这些系统也往往更具生物相容性和可生物降解性，并且有利于在生物制药和环境应用中使用。还对基于 PNIPAAm 的聚合物纳米复合材料进行了综述，其中无机或碳纳米材料的结合创建了协同系统，该系统往往比单个组件更强大且适用范围更广。 © 2019 Wiley periodicals, Inc. J. Appl。聚合物。科学。 2020 , 137 , 48770。

更新日期：2020-03-26

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