Two new α-pyrone derivatives, udagawanones A (1) and B (2), along with the known compounds (Z)-4-hydroxy-3-(3-hydroxy-3-methylbut-1-en-1-yl)benzoic acid (3), isosclerone (4), cyclo-(L-Leu-L-Pro) (5), and cyclo-(L-Pro-L-Tyr) (6), were isolated from cultures of the endophyte Neurospora udagawae. Their structures were elucidated by extensive spectroscopic methods and single crystal X-ray diffraction. Both compounds feature oxidized functionalities at the C-2 position not previously observed in other tetrasubstituted α-pyrones from fungi. Compound 1 exhibited moderate antibacterial (vs. Staphylococcus aureus) and antifungal (vs. Rhodoturula glutinis) activities and cytotoxicity against KB3.1 cells.

两种新的α-吡喃酮衍生物udagawanones A（1）和B（2）以及已知的化合物（Z）-4-羟基-3-（3-羟基-3-甲基丁-1-烯-1-基）从内生菌神经孢菌的培养物中分离出苯甲酸（3），异位酮（4），环-（L -Leu- L -Pro）（5）和环-（L -Pro- L -Tyr）（6）。udagawae。通过广泛的光谱学方法和单晶X射线衍射阐明了它们的结构。两种化合物在C-2位置均具有氧化功能，这在真菌的其他四取代α-吡喃酮中以前未见到。化合物1对KB3.1细胞表现出中等的抗菌作用（相对于金黄色葡萄球菌）和抗真菌作用（相对于Rhodoturula glutinis）。