Pectin-GPTMS-Based Biomaterial: toward a Sustainable Bioprinting of 3D scaffolds for Tissue Engineering Application.,Biomacromolecules

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Pectin-GPTMS-Based Biomaterial: toward a Sustainable Bioprinting of 3D scaffolds for Tissue Engineering Application.
Biomacromolecules ( IF 5.5 ) Pub Date : 2019-12-17 , DOI: 10.1021/acs.biomac.9b01332
Anna Lapomarda _{1,

2} , Aurora De Acutis _{1,

2} , Irene Chiesa _{1,

2,

3} , Gabriele M Fortunato _{1,

2} , Francesca Montemurro ₁ , Carmelo De Maria _{1,

2} , Monica Mattioli Belmonte ₄ , Riccardo Gottardi _{3,

5} , Giovanni Vozzi _{1,

2}

Affiliation

Developing green and nontoxic biomaterials, derived from renewable sources and processable through 3D bioprinting technologies, is an emerging challenge of sustainable tissue engineering. Here, pectin from citrus peels was cross-linked for the first time with (3-glycidyloxypropyl)trimethoxysilane (GPTMS) through a one-pot procedure. Freeze-dried porous pectin sponges, with tunable properties in terms of porosity, water uptake, and compressive modulus, were obtained by controlling GPTMS content. Cell experiments showed that GPTMS did not affect the cytocompatibility of pectin. The addition of GPTMS improved the printability of pectin due to an increase of viscosity and yield stress. Three-dimensional woodpile and complex anatomical-shaped scaffolds with interconnected micro- and macropores were, therefore, bioprinted without the use of any additional support material. These results show the great potential of using pectin cross-linked with GPTMS as biomaterial ink to fabricate patient-specific scaffolds, which could be used to promote tissue regeneration in vivo.

中文翻译：

基于果胶-GPTMS的生物材料：面向组织工程应用的3D支架的可持续生物打印。

开发可再生资源中可通过3D生物打印技术进行处理的绿色无毒生物材料，是可持续组织工程学面临的新挑战。在这里，来自柑橘类果皮的果胶通过单锅法首次与（3-环氧丙氧基丙基）三甲氧基硅烷（GPTMS）交联。通过控制GPTMS的含量，可以得到冻干的多孔果胶海绵，其孔隙率，吸水率和压缩模量具有可调性。细胞实验表明，GPTMS不会影响果胶的细胞相容性。由于粘度和屈服应力的增加，GPTMS的添加改善了果胶的可印刷性。因此，具有相互连接的微孔和大孔的三维木桩和复杂的解剖学形状的支架，无需使用任何其他支持材料即可进行生物打印。这些结果表明，使用与GPTMS交联的果胶作为生物材料墨水具有巨大的潜力，可以制造针对患者的支架，该支架可用于促进体内组织再生。

更新日期：2019-12-18

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