Abnormal neuroanatomic brain networks have been reported in schizophrenia, but their characterization across patients with psychotic disorders, and their potential alterations in nonpsychotic relatives, remain to be clarified. Participants recruited by the Bipolar and Schizophrenia Network for Intermediate Phenotypes consortium included 326 probands with psychotic disorders (107 with schizophrenia (SZ), 87 with schizoaffective disorder (SAD), 132 with psychotic bipolar disorder (BD)), 315 of their nonpsychotic first-degree relatives and 202 healthy controls. Single-subject gray matter graphs were extracted from structural MRI scans, and whole-brain neuroanatomic organization was compared across the participant groups. Compared with healthy controls, psychotic probands showed decreased nodal efficiency mainly in bilateral superior temporal regions. These regions had altered morphological relationships primarily with frontal lobe regions, and their network-level alterations were associated with positive symptoms of psychosis. Nonpsychotic relatives showed lower nodal centrality metrics in the prefrontal cortex and subcortical regions, and higher nodal centrality metrics in the left cingulate cortex and left thalamus. Diagnosis-specific analysis indicated that individuals with SZ had lower nodal efficiency in bilateral superior temporal regions than controls, probands with SAD only exhibited lower nodal efficiency in the left superior and middle temporal gyrus, and individuals with psychotic BD did not show significant differences from healthy controls. Our findings provide novel evidence of clinically relevant disruptions in the anatomic association of the superior temporal lobe with other regions of whole-brain networks in patients with psychotic disorders, but not in their unaffected relatives, suggesting that it is a disease-related trait. Network disorganization primarily involving frontal lobe and subcortical regions in nonpsychotic relatives may be related to familial illness risk.

中文翻译：

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精神障碍中的大脑灰质网络组织。


精神分裂症患者的神经解剖学大脑网络异常已有报道，但其在精神障碍患者中的​​特征及其在非精神病亲属中的潜在改变仍有待澄清。中间表型双相情感障碍和精神分裂症网络联盟招募的参与者包括 326 名患有精神障碍的先证者（107 名患有精神分裂症 (SZ)、87 名患有分裂情感性障碍 (SAD)、132 名患有精神病性双相情感障碍 (BD)）、315 名非精神病性先证者。直系亲属和202名健康对照。从结构 MRI 扫描中提取单个受试者的灰质图，并对参与者组之间的全脑神经解剖组织进行比较。与健康对照相比，精神病先证者的淋巴结效率降低主要发生在双侧颞上区。这些区域主要改变了与额叶区域的形态关系，其网络水平的改变与精神病的阳性症状相关。非精神病患者的前额皮质和皮质下区域的节点中心性指标较低，而左侧扣带皮层和左侧丘脑的节点中心性指标较高。诊断特异性分析表明，SZ 个体双侧颞上区的淋巴结效率低于对照组，SAD 先证者仅在左上回和颞中回表现出较低的淋巴结效率，而精神病性 BD 个体与健康个体没有表现出显着差异。控制。 我们的研究结果提供了新的证据，证明精神障碍患者的上颞叶与全脑网络其他区域的解剖学关联存在临床相关的破坏，但在其未受影响的亲属中却没有，这表明这是一种与疾病相关的特征。非精神病亲属中主要涉及额叶和皮质下区域的网络紊乱可能与家族性疾病风险有关。